Hi Tim:
Thanks, does this version of nmqual get nmvi level 1.1 upgrade?
Sam
Dear NMUSERS,
NMQual version 6.1.1 is available at
http://metruminstitute.org/downloads/nmqual/. It implements fixes for
NONMEM bugs 4 and 5, as described in NONMEM Bug Alert #4.
Regards,
Tim Bergsma
Metrum Resea
Hi Zheng:
It is complaining the CL1. You need to replace all CL1 with CL. But
you have other problems in your $INPUT statement and the data set too.
Sam
Dear All:
why do I get following error message with the following code? Any
opinions regarding this problem and code will be highly appr
sky, Ph.D.
President, QuantPharm LLC
web:www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel:(301) 767 5566
Sam Liao wrote:
Dear NONMEM users:
Can someone please help me to solve this problem with a band matrix?
$OMEGA BLOCK(4)
0.09 ;BSV_V1C
0.07 0.09;BSV_CLC
0
e out why this band matrix not permissible.
Sam Liao
<http://www.cognigencorp.com/nonmem/nm/96mar232001.html>
Dear Sébastien:
You may be able to avoid this problem in the second $TABLE by adding
NOAPPEND option because it will not include DV, PRED, RES, WRES at the
end of the record.
Best regards,
Sam Liao
Dear All,
I am working on a PK model, that can be implemented using $PRED but
requires the
this problem.
Sam Liao
Pharmax Research
Dear Sébastien:
You may be able to avoid this problem in the second $TABLE by adding
NOAPPEND option because it will not include DV, PRED, RES, WRES at the
end of the record.
Best regards,
Sam Liao
Dear All,
I am working on a PK model, that c
Dear Galadriel:
You would need to provide an estimate of D2, the duration of zero-order
input to CMT=2 in your model.
Sam Liao
Pharmax Research
Dear all,
I tried to build up a combined absorption model (zero order + first
order)using ADVAN 4, following is the control file I found in the
PDx
e out all the "COM(x)="
Best regards,
Sam Liao
Pharmax Research
Hi, Everybody,
I have used Andrew Hooker's code to calculate CWRES with NONMEM 6.1
before (the NONMEM verbatim code and the R code for calculation). Now
our NONMEM has been upgraded to 6.2, and I am having problems with
Dear Ayyappa:
I think you will find the following nmusers net post useful for your
model. Alison had kindly provided some code for a EHC model.
Best regards,
Sam Liao
Pharmax Research
===
*Enterohepatic Recirculation Model
observed one peak after each meals and there were
three meals each day.
Best regards,
Sam Liao
Pharmax Research
Dear Sam and Ayyappa,
The postings that Sam mentioned are obsolete.
The first of the model time examples ("help mtime") suggests a
better technique for modelling EHC u
Dear Xia:
Please see the NONMEM online manual, under examples, there is PK PD
simultaneous 1 example. I think this is exactly what you are asking.
Sam Liao
Pharmax Research
Hi
Does anybody have example to share for POP PK/PD (PD is expressed as
Emax model in $ERR block) simultaneous
VARIABLES
ERROR OCURRED WHILE ATTEMPTING TO OBTAIN INITIAL VALUES FOR DY/DT"
Sam Liao
= sim02.lst =
$PROB A TMDD MODEL
$INPUT C ID TIME DV AMT RATE
According to ICON, this is due to the size of the RAM on your PC. If you
have less than 3 GB of RAM and running the 'big' nm7 job, it will not allow
you to run more than 2 jobs at once. You may need to increase your RAM to
6GB to solve this problem.
Best regards,
Sam Liao
Pharma
Dear NONMEM team:
I have two nm7 questions.
I have a PKPD model using ADVAN13 to solve the ODE. It took 12 hours to
complete the $EST step with rounding error.
But it's been over 15 hours running the $COV step with UNCONDITIONAL option.
This is much longer time than I expected. Could t
Dear Tom:
I have a question on the different results from NM5.1 vs. NM6.20. I have PK
data fitted by a two-compartment open model with first-order absorption.
The results from NM5.10 and NM6.20 are quite different in that all BSV of
CL/F, V2/F, V3/F, etc were smaller, yet the proportional residue
Dear NONMEM team:
I am using NONMEM 7.10, ADVAN13 on a PK model with very stiff functions. I
am getting this error in ISODA code -1 and sometime -6 in some of the
subjects. Can someone please tell me what this mean and how to fix it.
Best regards,
Sam Liao
Pharmax Research
Dear NONMEM team:
To run the M3 method to handle BQL samples, we have to use method=LAPLACIAN
NUMERICAL SLOW in NM6. Can we use the new methods in NM7 such as IMP, SAEM
or BAYES if we have to run the M3 method?
Best regards,
Sam Liao
Pharmax Reseach
From: owner-nmus...@globomaxnm.com
MUST BE USED"
Sam Liao
Pharmax Research
==
$EST METHOD=IMP INTERACTION NITER=200 CTYPE=3 ISAMPLE=1000 PRINT=10 NOABORT
SIGL=3 SIG=1
$EST METHOD=BAYES INTERACTION NBURN=100 NSAMPLE=3000 NOABORT FILE=
If you are using NONMEM v6 or later, add this line before $DES
A_0(1)= KIN/KOUT
Sam Liao
Pharmax Research
Dear NMusers,
I have a question I would like your help. The data I have is only the
dynamic data since we didn't give dose to the animal. I am trying to
capture the nature of di
Dear nmusers:
I would like to ask some help on xpose4. I am trying to explore the
relationship between BOV and OCC. The xpose4 only show one record per
subject. Therefore, only the records with OCC=1 were displayed. Any work
around on this problem?
Best regards,
Sam Liao
Pharmax Research
Dear Yamin:
This is caused by the 560 time points that exceeded the max limit of
observations. For SIZE_big, the limit is 500 (see the partial codes below
for nm7). You need to change NO=500 to something bigger.
Sam Liao
Pharmax Research
Dear Markus:
The error message indicated that you need to use EVID=4 to reset your system
in the second dose event.
Sam Liao
Pharmax Research Inc.
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of markus joerger
Sent: Thursday, June 03, 2010 8:20 AM
I have a four levels covariate model. Hope this is useful to you.
Sam Liao
Pharmax Research
==
RA1=0
RA2=0
RA3=0
IF(RACE.EQ.7) RA1=1
IF(RACE.EQ.8) RA2=1
IF(RACE.GT.8) RA3=1
TVCL= TVCL *(1 + THETA(33)*RA1+ THETA(34)*RA2+ THETA(35)*RA3
0, if your model needs 100
theta. Hope this help.
Best regards,
Sam Liao
PharMax Research Inc.
PO Box 15661
Newport Beach, CA 92659
Phone: (201)-988-2043
Fax: (720)-294-6783
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Lindauer, A (And
Dear Nick:
I have encounter a problem using nmgo in WFN.
For one run4.mod, when I used the 'nmgo run4', the program fail to run. When I
check the run4.nm7 folder, the run4.mod was copied only partially and stop.
Other run.mod were running fine. But I cannot tell what is the problem with
this r
26, 2012 10:23 PM
To: 'nmusers'
Subject: [NMusers] Re: WFN problem
Sam,
Please send me the run4.mod control stream and a sample of data so I can
investigate.
Impossible to help you without any further information :-)
Nick
On 27/10/2012 4:35 p.m., Sam Liao wrote:
> Dear Nick:
>
initial estimates from the best
run from parallel retries. I believe the MPI was not involved in the
parallel_retries. If anyone know how to fix this problem, please let me
know.
Best regards,
Sam Liao
PharMax Research Inc.
PO Box 15661
Newport Beach, CA 92659
Phone: (201)-988-2043
Fax: (720)-294-6783
is problem? Somehow, the $SIZE statement in
the control stream was ignored.
--
Sam Liao
Pharmax Research Inc.
14 Upland,
Irvine, CA 92602
Phone: 201-9882043
efax: 720-2946783
www.pharmaxresearch.com
Dear Robert,
I did not have –prdefault anywhere in my command.
Best regards,
Sam Liao
Pharmax Research Inc.
14 Upland,
Irvine, CA 92602
Phone: 201-9882043
efax: 720-2946783
www.pharmaxresearch.com
On 6/17/2015 2:21 PM, Bauer, Robert wrote:
Do not add –prdefault on your command line.
Robert J
Dear Nick,
Yes, it works! Thanks a lot.
Best regards,
Sam Liao
Pharmax Research Inc.
14 Upland,
Irvine, CA 92602
Phone: 201-9882043
efax: 720-2946783
www.pharmaxresearch.com
On 6/17/2015 1:59 PM, Nick Holford wrote:
Sam
,
set args7=
That will remove the WFN default argument -prdefault and
Dear Thierry,
External VPC would be a useful method to compare your data with the
published PPK model.
Best regards,
Sam Liao, Ph.D.
Pharmax Research, Inc.
On 11/20/2015 9:44 AM, Buclin Thierry wrote:
Dear NMusers,
We have a small series of some 100 blood measurements in 13
neutropenic
your TMDD modeling.
Best regards,
Sam Liao, PhD.
Pharmax Research
On 1/4/2017 8:53 AM, Zhu, Penny wrote:
Dear all
Sorry to bother you.
I have encountered a problem with a complex model, involve a full TMDD
PK model lined to a complicated multi-compartment PD model. I was only
doing a
Dear Lisa,
Our NONMEM license will expire by 14th July, 2018.
Please send me the renewal package soon as possible.
Best regards,
Sam Liao, PhD.
Pharmax Research, Inc.
On 7/3/2018 7:00 AM, Wilhelm-Lear, Lisa wrote:
Below please find the links to our website regarding the above noted
setting A(4) to zero in the statement of
control stream.
Is there any work around of this problem?
Best regards,
Sam Liao
On 11/7/2019 7:17 AM, Farrell, Colm wrote:
At ICON, it’s our people that set us apart.
As a global provider of drug development solutions, our work is
serious business
Thanks for all your quick reply.
I tried to add one dummy record at the starting time of all subsequent
treatments to get cumulative AUC values to correct the cumulative AUC
after each treatment.
Best regards,
Sam Liao
On 11/8/2019 11:18 AM, Matthew Fidler wrote:
Hi Sam,
Leonid is
Hi,
I have a question on ADVAN5 and ADVAN7 related to dose event record.
This is a general linear model.
Can these two models allow multiple doses in compartment 1 and 3,
simultaneously?
Best regards,
Sam Liao
Pharmax Research, Inc.
On 7/19/2018 11:50 AM, Bauer, Robert wrote:
NONMEM
regards,
Sam Liao,
Pharmax Research
> On August 5, 2020 9:18 AM Patricia Kleiner wrote:
>
>
> Dear all,
>
> I am developing a PK model for a drug administered as a long-term infusion
> of 48 hours using an elastomeric pump. End of infusion was documented, but
> sometimes
Just realized the typical value of this estimate cannot be 1.0. You may need
other transformation.
Sam
> On August 5, 2020 9:59 AM Sam Liao wrote:
>
>
> Dear Patricia,
> This distribution might to analogous to relative bioavailability estimate,
> which is bounded between
Dear Wenping,
Congratulation. Thanks for the hard work.
Best regards,
Sam
On April 22, 2021 4:56 AM Wang, Wenping <
wenping.w...@novartis.com> wrote:
In August 2018, the nlmixr team announced th
n du läsa här:
http://www.uu.se/om-uu/dataskydd-personuppgifter/
E-mailing Uppsala University means that we will process your personal
data. For more information on how this is performed, please read
here: http://www.uu.se/en/about-uu/data-protection-policy
--
Sam Liao
Pharmax Research Inc.
1
Dear Dennis,
" NUMERICAL DIFFICULTIES WITH INTEGRATION ROUTINE.
MAXIMUM NO. OF EVALUATIONS OF DIFFERENTIAL EQUATIONS, 100,
EXCEEDED. "
This seem to indicate that is due to large gap from the first dose time
to the next, causing the difficulty in numerical integration. For these
subject
To avoid negative F, you can use logit transformation to define F.
may need to show your nm code to understand the problem.
Sam
On 03/11/2025 6:39 AM PDT Marie Rajerison wrote:
Dear NM users
I am running an
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