RE: [NMusers] error (157) forrtl: severe

Our compiler is Compaq Visual Fortran (latest version). We appreciate your thoughts on that. __ Joachim GREVEL, Ph.D. MERCK SERONO International S.A. Exploratory Medicine 1202 Geneva Tel: +41.22.414.4751 Fax: +41.22.414.3059 Email: [EMAIL PROTEC

RE: [NMusers] error (157) forrtl: severe

We run NONMEM VI without the recent bug fixes in a "naked" fashion on the server, and with "wings" on the PCs. Our compiler is Compaq Visual Fortran (latest version). We appreciate your thoughts on that. __________ Joachim GREVEL, Ph.D. MERCK S

RE: [NMusers] error (157) forrtl: severe

with "wings" on the PCs. Our compiler is Compaq Visual Fortran (latest version). We appreciate your thoughts on that. __ Joachim GREVEL, Ph.D. MERCK SERONO International S.A. Exploratory Medicine 1202 Geneva Tel: +41.22.414.4751 Fax: +41.22.41

[NMusers] error (157) forrtl: severe

ith "wings" on the PCs. Our compiler is Compaq Visual Fortran (latest version). We appreciate your thoughts on that. __________ Joachim GREVEL, Ph.D. MERCK SERONO International S.A. Exploratory Medicine 1202 Geneva Tel: +41.22.414.4751 Fax: +41.22.41

[NMusers] AUC Calculation in Simulation with and without EST

. Joachim __ Joachim GREVEL, Ph.D. MERCK SERONO International S.A. Exploratory Medicine 1202 Geneva Tel: +41.22.414.4751 Fax: +41.22.414.3059 Email: [EMAIL PROTECTED] Paul wrote: I have data from PO, IP, and SQ(pump) infusions of this compound that I am

[NMusers] Covariate hierarchy

x27;t we write Phase I (dose escalation) protocols for just about all new drugs (not only anticancer drugs) with doses based on the size of the volunteers (patients)? What do my colleagues from industry and the regulatory agencies think? Joachim __ Jo

Re: [NMusers] NONMEM and g77

production phase. Any other users out there who are happy with gfortran as substitute for g77 as compiler? Joachim __ Joachim GREVEL, Ph.D. Modeling and Simulation MERCK SERONO International S.A. Exploratory Medicine 1202 Geneva Tel: +41.22.414.4751 Fax

[NMusers] Scaling for pediatric study planning

allometrically scale a first-order rate constant of absorption after oral dosing? b) how do we allometrically scale a first-order rate constant of absorption from a subcutaneous injection site? Thank you for your thoughts, Joachim __ Joachim GREVEL, Ph.D. MERCK

Re: [NMusers] Validation Strategy for NONMEM

with a grid engine. 7. It all takes more time than you think: make generous budgets and time lines. I hope I helped more than I confused, Joachim __ Joachim GREVEL, Ph.D. MERCK SERONO International S.A. Exploratory Medicine 1202 Geneva Tel:

Re: [NMusers] Validation Strategy for NONMEM

system administrator and modeler at the same time. Joachim __ Joachim GREVEL, Ph.D. MERCK SERONO International S.A. Exploratory Medicine 1202 Geneva Tel: +41.22.414.4751 Fax: +41.22.414.3059 Email: [EMAIL PROTECTED] "A.J. Rossini" <[EMAIL PR

Re: [NMusers] Validation Strategy for NONMEM

him __ Joachim GREVEL, Ph.D. MERCK SERONO International S.A. Exploratory Medicine 1202 Geneva Tel: +41.22.414.4751 Fax: +41.22.414.3059 Email: [EMAIL PROTECTED] "Jun Shen" <[EMAIL PROTECTED]> 10/22/2008 04:08 PM To [EMAIL PROTECTED] cc nmusers@globom

RE: [NMusers] Validation Strategy for NONMEM

mers, review of modeling results and conclusions, continued education (which involves also this user network). Indeed, the NONMEM user network is listed in our risk analysis as a means to mitigate. Thank you for your continued interest, Joachim ______ Joachim GREV

Re: [NMusers] unscientific poll

, the discussions on our usernet are extremely relevant to our daily modeling work. Cheers to our usernet! Joachim __ Joachim GREVEL, Ph.D. MERCK SERONO International S.A. Exploratory Medicine 1202 Geneva Tel: +41.22.414.4751 Fax: +41.22.414.3059 Email: [EMAIL PROT

Re: [NMusers] NONMEM code for Mixture Model

fies only one population. Good luck, Joachim ______ Joachim GREVEL, Ph.D. Merck Serono S.A. - Genève Human Pharmacology 1202 Geneva Tel: +41.22.414.4751 Fax: +41.22.414.3059 Email: joachim.gre...@merckserono.net nidal.alhun...@gmail.com Sent by: owner-nmus...@g

Re: [NMusers] NONMEM code for Mixture Model

(ETA(1)) Joachim __ Joachim GREVEL, Ph.D. Merck Serono S.A. - Genève Human Pharmacology 1202 Geneva Tel: +41.22.414.4751 Fax: +41.22.414.3059 Email: joachim.gre...@merckserono.net "Huali Wu" 03/13/2009 03:56 PM To , cc Subject Re: [NMuse

Re: [NMusers] NONMEM code for Mixture Model

us about your findings, Joachim __________ Joachim GREVEL, Ph.D. Merck Serono S.A. - Genève Human Pharmacology 1202 Geneva Tel: +41.22.414.4751 Fax: +41.22.414.3059 Email: joachim.gre...@merckserono.net joachim.gre...@merckserono.net Sent by: owner-nmus...@globomaxnm.com 03/13/2009 08:23 AM To n

Re: [NMusers] Log transformation of concentration

pointing that out in his workshop. Joachim __ Joachim GREVEL, Ph.D. Merck Serono S.A. - Genève Human Pharmacology 1202 Geneva Tel: +41.22.414.4751 Fax: +41.22.414.3059 Email: joachim.gre...@merckserono.net Leonid Gibiansky Sent by: owner-nmus

RE: [NMusers] outsourcing PK/PD analysis - help wanted

Hi Pavel, Please, look up an oldtimer with decades of experience: www.bastinc.eu Would be happy to do business with you, Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited BioCity Nottingham Pennyfoot Street Nottingham, NG1 1GF Tel: +44 (0)115 8120497

RE: [NMusers] AW: CompareModels

Dear Dirk, If your full model has 4 parameters more than your reduced model, and you estimate all four of them, it does not matter how many observations contribute to each of them. Thus you should evaluate Diff_OFV at 4 degrees of freedom. Happy modelling, Joachim Joachim Grevel

RE: [NMusers] Modeling Cmin and Tmin

ulated data files with R or SAS and report the distribution of the Cmin and Tmin you found. Please, come back with more questions in case I have confused you, Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited BioCity Nottingham Pennyfoot Street Nottingham, NG1 1GF Tel:

RE: [NMusers] Modeling Cmin and Tmin

these predictions in the output table and play with them as you like. Hope this helps you furher, Joachim From: Friederike Kanefendt [mailto:friederike.kanefe...@uni-bonn.de] Sent: 06 April 2011 14:05 To: Joachim Grevel; nmusers@globomaxnm.com Subject: AW: [NMusers] Modeling Cmin

RE: [NMusers] Time to Event Model

easing NSIG and SIGL I have not checked your code in detail, but this would be my first choice for improvement. Good luck! Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited BioCity Nottingham Pennyfoot Street Nottingham, NG1 1GF Tel: +44 (0)115 8120497

RE: [NMusers] Time to Event Model

an end. What's required is "Fingerspitzengefuehl" (sorry, my Anglophone friends) Joachim -Original Message- From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Friederike Kanefendt Sent: 15 August 2011 13:13 To: Nick Holford; Joachim

RE: [NMusers] Nonmem 7 installation

Windows in the installation guide to NONMEM. Good Luck, Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited BioCity Nottingham Pennyfoot Street Nottingham, NG1 1GF Tel: +44 (0)115 8120497 From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On

RE: [NMusers] Bayesian networks

Dear Svetlana, A good starting point would be the "NONMEM Users Guide Introduction to NONMEM 7.2.0" chapter I.24 p40ff plus examples. Not sure what you call "Bayesian networks". Good Luck, Joachim -Original Message- From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com

[NMusers] OMEGA priors using modes of inverse Wishart matrix

Wishart matrix in his historic contributions to NMusers, but again I could not find out how to obtain it. If it does not happen in NONMEM, is there a tool in R that can give me that matrix? Your help is greatly appreciated, Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited

RE: [NMusers] OMEGA priors using modes of inverse Wishart matrix

use NWPRI (i.e. with the inverse wishart for OMEGA's), or TNPRI, which uses a multivariate normal for the OMEGA's. Do you have any idea when to use either of these two possible implementations ? Thanks, Coen >>> "Joachim Grevel" 02/22/12 2:11 PM >>> Dea

RE: [NMusers] OMEGA priors using modes of inverse Wishart matrix

1:09 PM To: Mats Karlsson; 'Joachim Grevel'; 'Coen van Hasselt'; 'nmusers' Subject: RE: [NMusers] OMEGA priors using modes of inverse Wishart matrix Hi An appropriate value for dof of the IW is difficult to determine. While it can be set at n-1 from a prior this is som

RE: [NMusers] OMEGA priors using modes of inverse Wishart matrix

instruction and use simply the covariance matrix of the previous NONMEM analysis of the large data file: $OMEGA BLOCK(2) 0.000131 FIX 0.191 0.000627 $THETA (138 FIX) There is not really a big difference in my example. Joachim Joachim Grevel, PhD Scientific Director BAST

RE: [NMusers] Using MIXture model to fit 1 compartment vs 2 compartment model

drug (CVVH - what is that?), but it may be sufficient to obtain individual predictions (to relate dialysis flow rate to individual clearance estimates?). The technicalities of setting up informative priors have been discussed in this forum recently. Good luck, Joachim Joachim Grevel, PhD

RE: [NMusers] Different EBE estimation between original and enriched dataset with MDV=1

did a bootstrap. Good luck, Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited Loughborough Innovation Centre Charnwood Building Holywell Park, Ashby Road Loughborough, LE11 3AQ Tel: +44 (0)1509 222908 Confidentiality Notice: This message is private and may

RE: [NMusers] When will NONMEM UsersNet Archive be searchable again?

://www.mail-archive.com/nmusers@globomaxnm.com/ On Sat, Jan 26, 2013, at 07:52 AM, Joachim Grevel wrote: http://www.cognigencorp.com/index.php/cognigen/resources_nonmem Dear NONMEM users, For several months now I cannot search the NONMEM usersnet archive. Can somebody please tell me where

[NMusers] Modeller position open at BAST

no Send CV to Joachim Grevel (jgre...@bastinc.eu) More informationwww.bastinc.eu Joachim Grevel, PhD Scientific Director BAST Inc Limited Loughborough Innovation Centre Charnwood Building Holywell Park, Ashby Road Loughborough, LE11 3AQ Tel

[NMusers] Participate in CTS development

test our successive prototypes for free: http://www.bastinc.eu/component/smartformer/?formid=8 We are looking forward to working with you. Kind regards, Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited Loughborough Innovation Centre Charnwood Building Holywell

[NMusers] position at BAST

Midlands, England, UK Work from home no Send CV to Joachim Grevel ( <mailto:jgre...@bastinc.eu> jgre...@bastinc.eu) More information <http://www.bastinc.eu> www.bastinc.eu Joachim Grevel, PhD Scientific Director BAST Inc Limited

[NMusers] Position at BAST

best, Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited Loughborough Innovation Centre Charnwood Building Holywell Park, Ashby Road Loughborough, LE11 3AQ Tel: +44 (0)1509 222908

RE: [NMusers] Population PKPD using hair drug concentration

Dear Leonid and Bernard, Why not treat hair like a urine compartment that is not emptied until the hair is pulled out with the root? NONMEM user guides contain all you need to model a "collection compartment" like urine/hair. Have fun, Joachim Joachim Grevel, PhD Scientific Directo

RE: [NMusers] unbalanced data set

opinions. Good luck, Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited Science & Enterprise Park Loughborough University Loughborough, LE11 3AQ United Kingdom Tel: +44 (0)1509 222908 www.bastinc.eu <http://www.bastinc.eu/> From:

RE: [NMusers] ASCO and pharmacometrics

been to ASCO either. Good luck, Joachim Joachim Grevel, PhD Scientific Director BAST Inc Limited Science & Enterprise Park Loughborough University Loughborough, LE11 3AQ United Kingdom Tel: +44 (0)1509 222908 www.bastinc.eu <http://www.bastinc.eu/> From: