Re: [NMusers] inexplicit equations in PRED

=EXACT A(13)=0.001 $AES E(13)=A(9)-A(13)-A(13)*A(10)/(KSS+A(13))-A(13)*A(12)/(KSS2+A(13)) $DES ... $ERROR Y = A(13)+EPS(1) Regards, Katya -- Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web: www.quantpharm.com Email: egibian...@quantpharm.com Tel:

Re: [NMusers] inexplicit equations in PRED

)*V1 - KINT*A(3)*V1*A(2)/(KD+A(3)) DADT(2)= KSYN - KDEG*A(2) -(KINT - KDEG)*A(3)*A(2)/(KD+A(3)) Regards, Katya - Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web: www.quantpharm.com Email: EGibiansky at quantpharm.com Tel: (301)-717-7032 Sam wrote:

Re: [NMusers] inexplicit equations in PRED

OBSERVATIONS) K11 = A(1)/V1-A(2)-KD C1 = 0.5*(K11+ SQRT(K11*K11+4*KD*A(1)/V1)) Then, use C1 instead of F everywhere where you used F, and output C1 in the $TABLE. Regards, Katya - Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web: www.quantpharm.com E

Re: [NMusers] simultaneous PK/PD

Hi Hauke, You can easily re-write the code to be non-nested, e.g. IF (M1H2.EQ.1.AND.C1.GT.0) IPRE = LOG(C1) IF (M1H2.EQ.1) THEN     IRES = DV-IPRE     W = EPS(1)*THETA(8)     Y = IPRE+W   ENDIF Regards, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC

Re: [NMusers] Piece-wise PD model

Brendan, The implementation of your piece-wise model is not correct. It should be EFFECT=AEFF*SLOPE1 IF(AEFF.GT.CHANGE) EFFECT=CHANGE*SLOPE1+(AEFF - CHANGE)*SLOPE2 Regards, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web: www.quantpharm.com Email: EGibiansk

Re: [NMusers] Autoinduction model - An increased clearance(day 1- 14)

often and where the observation times are. Non-continuous parameters are also a sourse of numerical problems. To make CL a continuous function of time, you need to have the function inside $DES and use T rather than TIME.  Regards, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPhar

Re: [NMusers] Question Re Calling nmfe7 from R

ow, or type SET > temp.txt to have all the variables be printed to the file temp.txt. Regards, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web: www.quantpharm.com Email: EGibiansky at quantpharm.com Tel: (301)-717-7032 On May 4, 2011, at 11:50 AM, Xiao Hu

Re: [NMusers] PAMAM-OH nanoparticles

to humans. Regards, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web: www.quantpharm.com Email: EGibiansky at quantpharm.com Tel: (301)-717-7032 On 6/2/2011 4:31 PM, Olinto Linares wrote: Thanks Matt for the suggestion. I am looking it.   Dear Ma

Re: [NMusers] Modeling Hemodialysis clearance

Dear Xiao, I agree with Jun's advise. You previous setting should not work as when you switch the compartment 3 off nothing changes for compartment 2, k23 stays the same as it was. Regards, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPhar

Re: [NMusers] Modeling Hemodialysis clearance

, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web: www.quantpharm.com Email: EGibiansky at quantpharm.com Tel: (301)-717-7032 On 7/21/2011 7:39 AM, Xiao Hu wrote: Dear Katya, Jun, Luann, and Cha

Re: [NMusers] lagged absorption and empirical input function

Dear Xiao, This is not correct. When you specify ALAG1, the delay will be applied to doses specified on the dosing records of the data file (i.e where AMT > 0), but not in the case of Pierre-Olivier's problem where input is explicitly defined in the control stream. Regards, Katya E

Re: [NMusers] time-dependent clearance model

eck whether relative standard errors are large). Regards, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web: www.quantpharm.com Email: EGibiansky at quantpharm.com On 3/4/2012 5:33 PM, Wang, Xiaofeng wrote:

Re: [NMusers] Error files when using multicore runs and psn ==> Fatal Error: Record SIZES is not valid

Hi Pascal, $SIZES should be before $PROB. It should be the first uncommented line in the file. Regards, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web: www.quantpharm.com Email: egibian...@quantpharm.com Tel: (301)

Re: [NMusers] THETA numbering

, Katya -- Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web: www.quantpharm.com Email: EGibiansky at quantpharm.com Tel: (301)-717-7032 On 10/3/2012 6:06 AM, Lindauer, A (Andreas) wrote: Dear all, When trying to execute a rather complex control stream with many THETAs, I get

Re: [NMusers] Issues with NONMEM 7.2/MPI

n the manager waits a very long time before it decides to reroute the work." Regards, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web: www.quantpharm.com Email: EGibiansky at quantpharm.com Tel: (301)-717-7032 On 11/4/2013 4:10 AM, Mayer, Michael wrote: Hi all,

Re: [NMusers] criteria for implementing BSV-V2 and BSV-Q

model with fewer random effects unless you see a real improvement of the model in diagnostic plots (including VPC). Regards, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web: www.quantpharm.com Email: EGibiansky at quantpharm.com On 3/19/2014 12:53 PM, H.C.A.M. Hazen

Re: [NMusers] Logic Expression in $DATA: ACCEPT or IGNORE

Hi Xinting, You can separate the condition into several statements. For example, if you need to accept (A=1 OR A=2) AND B<100 you instead can have 2 or 3 IGNORE statements (depending on the values A can have), say IGNORE=(B.GE.100) IGNORE=(A.GT.2) IGNORE=(A.LT.1) Regards, Katya Ekater

Re: [NMusers] Splitting the residual error

Dear Jon, We routinely use separate residual errors during absorption and later (say, a larger error in the first X hours), although I do not remember whether we published any of those models. Regards, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web:www.quantpharm

Re: [NMusers] Splitting the residual error

whether we published any of those models. Regards, Katya Ekaterina Gibiansky, Ph.D. CEO&CSO, QuantPharm LLC Web:www.quantpharm.com Email:egibian...@quantpharm.com <mailto:Email:egibian...@quantpharm.com> On 5/13/2016 6:37 AM, Mats Karlsson wrote: Dear Jon, As you point out the

[NMusers] Book announcement: Modeling in Biopharmaceutics, Pharmacokinetics and,Pharmacodynamics: Homogeneous and Heterogeneous approaches

Dear nmusers, Please see below the announcement from Dr. Panos Macheras Dear colleagues, This is to inform you about the publication of the second Edition of the Springer book, Modeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics: Homogeneous and Heterogeneous approaches Here is t

Re: [NMusers] Potential bug in NM 7.3 and 7.4.2

And one more question, do you have long lines - compared to 80 and to 300 characters that become shorter than these thresholds when you drop the third variable? Regards, Katya On 11/20/2018 10:01 AM, Leonid Gibiansky wrote: Never seen it. This will not solve the problem, but just for diagno

Re: [NMusers] LIBDECIMAL.LIB MISSING?

Hi Mark, I had the same problem with Intel FORTRAN 11. After spending some time ( may be not enough) trying to get it going, I changed to gfortran and gcc, and did not have any problems. Regards, Katya Ekaterina Gibiansky QuantPharm LLC QuantPharm.com > On Nov 29, 2019, at 1:04 PM, Mark S

[NMusers] antibiotics for Ukraine

Dear colleagues and friends, Many of you work for pharmaceutical companies. Now, when the war is raging in Ukraine, many of us are trying to help. A US based volunteer organization that has direct contacts in Ukraine, told us that Ukrainians are desperate for antibiotics. And we cannot buy ant

Re: [External email][NMusers] Sad news about Dr. Ludden

I second everything Steve, and Mark, and Diane said. All of us who were blessed to work alongside him will forever remember him with fondness and gratitude. And let's not forget that he was the only one who Stuart Beal trusted to take care of NONMEM and bring it forward into 21st century. Katy