Re: [NMusers] create simulation file for 5000 patients ?

2007-02-28 Thread Dennis Fisher
mark i know how to do it in excel. but, excel is the saturn next to my porsche (R). dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax: 1-415-564-2220 www.PLessThan.com On Feb 28, 2007, at 6:42 AM, Mark Sale - Next Level So

[NMusers] Sheiner/Rowland Advanced Methods PK/PD Course

2007-03-13 Thread Dennis Fisher
ONLY A FEW SEATS REMAIN. The Sheiner/Rowland Course Sunday, May 20, 2007 - Friday, May 25, 2007 San Francisco, California Course Organizer: Dennis Fisher MD, The "P <" Company Lecturers: Leon Aarons, PhD, University of Manchester Dennis Fisher MD, The "P <" Company M

[NMusers] PLT Tools: A Graphical Interface for the NONMEM System

2008-03-07 Thread Dennis Fisher
rom PLTsoft.com. The free version provides nearly all features (see Licensing for details). Licensing unlocks the remaining features. Installation is automatic (drag-and- drop), provided that NONMEM VI is already installed. Details, examples, and downloads are available at PLTsoft.com. D

[NMusers] PLT Tools: A Graphical Interface for the NONMEM System

2008-04-03 Thread Dennis Fisher
tails, examples, and downloads are available at PLTsoft.com. Dennis Fisher Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax: 1-415-564-2220 www.PLessThan.com

[NMusers] PLT Tools: A Graphical Interface for the NONMEM System

2008-05-02 Thread Dennis Fisher
The free version provides nearly all features (see Licensing for details). Licensing unlocks the remaining features. Installation is automatic (drag-and-drop), provided that NONMEM VI is already installed. Details, examples, and downloads are available at PLTsoft.com. Dennis Fisher Denni

[NMusers] Models that abort before convergence

2008-11-18 Thread Dennis Fisher
on), then yet a more complicated model yielded 3.0 significant digits. In this case, there is no problem (I can use this final model for bootstrap, VPC, etc.) but what if none of these models had converged. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessTha

[NMusers] Format for submission to FDA

2009-06-29 Thread Dennis Fisher
hat format. Should my client honor the request or should they explain to the project manager that NONMEM requires text files so we plan to submit these files in text format (either .txt or csv). Thanks for any insights on this. Dennis Dennis Fisher MD P < (The "P Less Than" Company)

[NMusers] PLT Tools: A Graphical Interface for the NONMEM System

2009-09-29 Thread Dennis Fisher
at PLTsoft.com. Questions can be directed to i...@pltsoft.com. Dennis Fisher Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax: 1-415-564-2220 www.PLessThan.com

[NMusers] PLT Tools will be at the ACoP meeting

2009-10-02 Thread Dennis Fisher
Connecticut. If you would like to see PLT Tools in action, please contact me at the meeting. Feel free to contact me via email if you would like to arrange a meeting. Dennis Fisher Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax:1-866

[NMusers] PROGRAM TERMINATED BY NP4F

2010-04-28 Thread Dennis Fisher
the problem resulted from missing entries or blanks in the dataset. That is not the case here. Are other explanations? Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com

[NMusers] PLT Tools version 3.0

2010-05-24 Thread Dennis Fisher
instructions; typically, this can be addressed with a one-line modification to a batch file that we provide. Additional support is available at supp...@pltsoft.com. Dennis Fisher and Steven Shafer * Requires a licensed NONMEM installation; NONMEM is available from ICON / Globomax. † R

[NMusers] forrtl: severe (174): SIGSEGV, segmentation fault occurred

2010-06-06 Thread Dennis Fisher
built with Intel Fortran, NONMEM 6 was built with G95. Any thoughts? Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com

[NMusers] NONMEM fails to produce tables in OS X

2010-08-03 Thread Dennis Fisher
satisfy Koch's postulates, I cannot confirm that the culprit was XCode 3.2.3. However, if you encounter this situation, I recommend reverting to the earlier version of XCode. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax:

[NMusers] ifort in OS X

2010-08-05 Thread Dennis Fisher
different solution. I have pasted their solution below. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com Dennis, We also had this problem a few weeks ago here at UCSF. As it turned ou

[NMusers] Windows installation NONMEM 7 with ifort

2010-10-29 Thread Dennis Fisher
or install program cannot be run > Installation Aborted The entire dialog is shown below. Is the NONMEM installer trying to do a 64-bit installation but only 32-bit Fortran is available? Any ideas? Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (

[NMusers] PLT Tools -- version 4.0

2011-05-26 Thread Dennis Fisher
Tools does not work with Wings for NONMEM (Holford). Details, examples, and downloads are available at PLTsoft.com. Questions can be directed to i...@pltsoft.com. Dennis Fisher Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax

[NMusers] PLT Data - A Graphical Interface to Create NONMEM Datasets (beta version)

2015-06-22 Thread Dennis Fisher
expects in the final stages of beta testing), I will fix them. And, I encourage feedback from users as to how to improve the interface and code. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com <http://www.plessthan.com/>

Re: [NMusers] ASCO and pharmacometrics

2016-04-07 Thread Dennis Fisher
commas (I cannot speak to that issue) but I truly doubt Nick’s claim that they don’t care about science — the advances in oncology in recent years have been remarkable. Dennis Fisher MD P < (The "P Less Than" Company) Phone: 1-866-PLessThan (1-866-753-7784) Fax: 1-866-PLessThan (1

Re: [NMusers] Log transformation of imputed BQL

2016-07-27 Thread Dennis Fisher
one thing that you could do is multiply all the values by 1000 (i.e., change the units) Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com <http://www.plessthan.com/> > On Jul 27, 2016, at 11:11 AM, Bharadwa

[NMusers] Use of ACCEPT in $DATA

2017-08-24 Thread Dennis Fisher
NMTRAN sees, I could specify that value. Any help would be appreciated. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com <http://www.plessthan.com/>

Re: [NMusers] Use of ACCEPT in $DATA

2017-08-24 Thread Dennis Fisher
Sergei I would accept that if the problem related to decimals. Your code does not apply to integers (please provide an example if that is the case) - so it would only apply if NMTRAN does something weird to integers. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone

Re: [NMusers] Use of ACCEPT in $DATA

2017-08-24 Thread Dennis Fisher
Colleagues My apologies — my question reflected a (complicated) error on my part. NMTRAN / NONMEM were doing the correct thing. Of note, Leonid proposed using .EQN — that does not appear to be necessary. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866

[NMusers] NONMEM vs. R for linear mixed-effects

2018-02-28 Thread Dennis Fisher
ches. Any thoughts as to a possible explanation? Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com <http://www.plessthan.com/>

Re: [NMusers] NONMEM vs. R for linear mixed-effects

2018-02-28 Thread Dennis Fisher
Leonid I omitted one critical piece of information: $INPUT PERIOD=ID I think that your approach implies an order to the data from different periods — whereas making PERIOD=ID allows NONMEM to see each treatment as a separate subject (i.e., the random effect) Dennis Dennis Fisher MD P

Re: [NMusers] NONMEM vs. R for linear mixed-effects

2018-02-28 Thread Dennis Fisher
slope from the NONMEM code — the NONMEM results matches R exactly. Conceptually, a common slope makes sense for this particular analysis. Problem solved — thanks for your thoughts. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan (1

Re: [NMusers] Using evid 0 before dosing

2019-11-06 Thread Dennis Fisher
alysis. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com <http://www.plessthan.com/> > On Nov 6, 2019, at 7:12 AM, Bill Denney wrote: > > Hi Carlos, > > It is commonly used. For m

Re: [NMusers] Using evid 0 before dosing

2019-11-06 Thread Dennis Fisher
function. If the error model is proportional, NONMEM will report an error (0/0). I agree that pre-dose samples > LOQ provide IMPORTANT information about assay precision. Were you evacuated during the fires? Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-

Re: [NMusers] OFV from different algorithms

2020-09-23 Thread Dennis Fisher
rged, they yielded quite similar parameter estimates, but the OF differed by 60 units. I will be interested to hear Bob Bauer's reply to this issue. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com <htt

Re: [NMusers] T in $DES

2021-07-06 Thread Dennis Fisher
xplain the inner workings. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com > On Jul 6, 2021, at 5:44 AM, Matts Kågedal wrote: > > Hi all, > I have a question regaring T in $DES. > I have a time-v

Re: [NMusers] Obtaining RSE%

2024-07-29 Thread Dennis Fisher
standard errors assured that the estimates were truly the global minimum, i.e., the value of the covariance step was not the estimate of SE. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com > On Jul 29, 2

[NMusers] NONMEM error

2024-12-05 Thread Dennis Fisher
val between doses, However, I have no idea if this is the explanation. And I am reluctant to change the dataset so I seek other solutions. Any ideas as to an explanation or a work-around? Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan

[NMusers] NONMEM error

2024-12-05 Thread Dennis Fisher
val between doses, However, I have no idea if this is the explanation. And I am reluctant to change the dataset so I seek other solutions. Any ideas as to an explanation or a work-around? Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan

[NMusers] NONMEM error

2024-12-06 Thread Dennis Fisher
community. Dennis Dennis Fisher MD P < (The "P Less Than" Company) Phone / Fax: 1-866-PLessThan (1-866-753-7784) www.PLessThan.com