Dear Nonmem users,
I am working with a double peaks PK model. I refered to a recent question
about this topic and tried the double absorption compartment model suggested
by somebody.
Howerver, in my real data, the Ka and Ke for each peak are different. The ka
of the first peak is greater than that
Dear NONMEM users,
I am working on a PK model and using the log-transformed concentration data.
I'v read some discussions in the NONMEM user group about the log-transformed
concentration. But I am still not very clear about this. Could anybody give
me a reason to do the transform on concentration?
LC
> web: www.quantpharm.com
> e-mail: LGibiansky at quantpharm.com
> tel:(301) 767 5566
>
>
>
>
>
> Chenguang Wang wrote:
>
>> Dear NONMEM users,
>>
>> I am working on a PK model and using the log-transformed concentration
>> data. I'v read
Dear Nele,
To figure out the error of NONMEM, you can change the sequence of your
OMEGAs,
$OMEGA BLOCK(3)
0.1 ;CL1
0.01 0.1 ;F1
0 0.01 0.1 ;CL2
Make the corresponding change in the $PK block.
Regards,
Chenguang
2009/4/14
>
> Dear all,
>
> I am trying to f
Dear NONMEM users,
I would like to do the first stage analysis of STS in NONMEM. I followed the
tips in NONMEM Topic 35 (
http://www.cognigencorp.com/nonmem/nmo/topic035.html) with some adaptations.
The control stream is partly listed below:
...
$SUBROUTINE ADVAN11 TRANS4
$PK
CL = THETA(1)*EXP(
Dear all,
I have found a negtive ETA shrinkage result in my model output. I did a
simple simulation with 1-compartement model via iv bolus administration, and
then refitted the simulated data with the same model and initial values. In
the NONMEM output (of NONMEM 7), I got ETAshrink(%): -2.0123E-0
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- Chenguang Wang
Chenguang Wang
Ph.D. in PKPD modelling at Leiden University
The Hague Area, Netherlands
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