> Pascal
> I don't know what the "first table law rule" is, but you are correct.
> The on-line help entry for $problem is wrong. $sizes may precede $problem.
> This help item will be fixed with nonmem 7.3.
> (My understanding is that nonmem 7.3 will be released in the summer of 2013.
> )
Se
; " INTEGER IIDX
> IF (ICALL.EQ.3) THEN
> " DO 100 I=1,NINDR
> " WRITE (70,*) IIDX(I),CNTID(I)
> " 100 CONTINUE
> ENDIF
>
> Could someone please tell me whether this is correct or not?
>
> Regards
> Daniel Röshammar
> Unit for Pharmacokinetics and Drug Metabolism
> Sahlgrenska Academy at Göteborg University
> Phone: +46 31 773 34 94
--
Alison Boeckmann
[EMAIL PROTECTED]
,1,0,1,1
> 41004,4,5,.,.,316,53.4,18.6,1,0,4,0
> 41004,4,10,.,.,291,53.4,18.6,1,0,4,0
> 41004,4,15,.,.,438,53.4,18.6,1,0,4,0
> 41005,4,0,325,1300,.,0.1,2.6,1,0,1,1
> 41005,4,0.25,4793.75,325,.,0.1,2.6,1,0,1,1
> 41005,4,5,.,.,26,0.1,2.6,1,0,4,0
> 41005,4,10,.,.,17,0.1,2.6,1,0,4,0
> 41005,4,15,.,.,79,0.1,2.6,1,0,4,0
> 41007,4,0,2500,1,.,3.7,5,1,0,1,1
> 41007,4,0.25,36875,2500,.,3.7,5,1,0,1,1
> 41007,4,5,.,.,70,3.7,5,1,0,4,0
> 41007,4,10,.,.,1566,3.7,5,1,0,4,0
> 41007,4,15,.,.,2680,3.7,5,1,0,4,0
>
> --
>
> Paul R. Hutson, Pharm.D.
>
> Associate Professor
>
> UW School of Pharmacy
>
> 777 Highland Avenue
>
> Madison WI 53705-
>
> Tel 608.263.2496
>
> Fax 608.265.5421
>
> Pager 608.265.7000, p7856
--
Alison Boeckmann
[EMAIL PROTECTED]
TIME-48
> IF(TIME.GT.TMAX+48) ABST=TIME-72
> IF(TIME.GT.TMAX+72) ABST=TIME-96
>
> is this the only way or could i do it in some other way too.
>
>
> Also could someone please explain me as to what exactly are the "newind"
> and
> "ICALL"function.
e
> doses and concentrations. Am I missing something?
>
> Thank you very much for your help!!!
>
> Paula Schaiquevich, PhD Postdoctoral Research Associate Pharmaceutical
> Sciences St.Jude Children's Research Hospital 332 North Lauderdale
> street Memphis, TN 38105 Danny Thomas Research Center Room D1034 Mail
> Stop 314 Phone: (901)-495-5938
>
> E-mail: [EMAIL PROTECTED]
>
>
>
--
Alison Boeckmann
[EMAIL PROTECTED]
ONLY WHEN EVENT TIME
> > INCREASES. E.G., DISPLAYED VALUES ASSOCIATED WITH THE FIRST EVENT
> > RECORD OF AN INDIVIDUAL RECORD ARE COMPUTED WITH (WITH LAST ADVANCE
> > TO) AN EVENT TIME OF THE PRIOR INDIVIDUAL RECORD.
> >
> > Kindly advice...MNS
> >
>
--
Alison Boeckmann
[EMAIL PROTECTED]
the syntax suggested by Tim Bergsma,
ftp://nonmemvi:[EMAIL PROTECTED]
However, I cannot make this work in Windows Internet Explorer,
only in the untitled screen that opens from the Page>Open Site ...
as described above.
--
Alison Boeckmann
[EMAIL PROTECTED]
igure 11.1, Vol 5 of the NONMEM manuals, it is depicted
> as a step-by-step algorithm, without any looping back). Can anyone
> point me to any rigorous discussion of this model building strategy?
>
> Mark Sale MD Next Level Solutions, LLC www.NextLevelSolns.com
>
>
>
--
Alison Boeckmann
[EMAIL PROTECTED]
ar for 2006
> Genzyme Corporation
> Senior Director, Pharmacokinetics
> 4545 Horizon Hill Blvd
> San Antonio, TX 78229 USA
> [EMAIL PROTECTED]
> phone: 210-949-8662
> fax: 210-949-8219
> blackberry cell: 210-315-2713
>
--
Alison Boeckmann
[EMAIL PROTECTED]
or the individual or entity named in
> the e-mail address. If you
> are not the intended recipient, you are hereby notified that any
> disclosure, copying, distribution, or reliance upon the contents of this
> e-mail is strictly prohibited.
> If you have received this e-mail transmission in error, please reply to
> the sender, so that ICON can arrange for proper delivery, and then please
> delete the message. Thank You.
>
>
>
>
>
>
>
>
>
>
>
--
Alison Boeckmann
[EMAIL PROTECTED]
Due to the problem stated
> above I am not using ADDL. Instead I have a dosing record at every time a
> dose enters the depot compartment. Will this circumvent the problem
> stated
> above? In other words does ALAG always have to be smaller than II and
> why?
>
>
>
> Ple
?
>
> Thanks!
> Pavel
--
Alison Boeckmann
[EMAIL PROTECTED]
Original question:
Sometimes the same subjects receive the same drug from different
batches. Potentially, half-life can be different accross batches.
Theoretically, it is easy to model if PKis linear because NONMEM
superimpose
Sorry, here are the remarks.
On Sat, 21 Apr 2007 10:51:39 -0700, "Alison Boeckmann"
<[EMAIL PROTECTED]> said:
> Please see attached remarks and files.
>
> --
> On Thu, 19 Apr 2007 14:54:11 + (GMT), [EMAIL PROTECTED] said:
> > Hello NONMEM Users,
&g
ically,
> it is easy to model if PKis linear because NONMEM superimposes
> single-dose processes to obtain predicted concentrations for multiple
> doses. Does enyone know how to implement it in NONMEM? Are there any
> classes or publications which can help?
>
> Thanks!
nt it in NONMEM? Are there any
> classes or publications which can help?
>
> Thanks!
> Pavel
--
Alison Boeckmann
[EMAIL PROTECTED]
$PROB batch1
$DATA dat1.txt IGNORE=#
$INPUT ID TIME AMT RATE CMT DV
$SUBR ADVAN1
$PK
F1=1
D1=1
ALAG1=1
K=1
S1=1+ETA(1)
$ERROR Y=F+ERR(1)
$OME
645 2828 ext 275 Fax: 716 645 3693 E-mail:
> >> [EMAIL PROTECTED]
> >>
> >
> > --
> > Nick Holford, Dept Pharmacology & Clinical Pharmacology University
> > of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New Zealand
> > email:[EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:373-7556
> > http://www.health.auckland.ac.nz/pharmacology/staff/nholford/
> >
> >
>
>
> --
> Ying HONG, PhD Department of Pharmaceutical Sciences University at
> Buffalo, SUNY C237 Cooke Hall, Buffalo, NY 14260
>
> Tel: 716 645 2828 ext 275 Fax: 716 645 3693 E-mail: [EMAIL PROTECTED]
>
>
--
Alison Boeckmann
[EMAIL PROTECTED]
rivileged information that is intended only for the individual or
> > entity named in the e-mail address. If you are not the intended
> > recipient, you are hereby notified that any disclosure, copying,
> > distribution, or reliance upon the contents of this e-mail is
> > strictly prohibited. If you have received this e-mail transmission
> > in error, please reply to the sender, so that ICON can arrange for
> > proper delivery, and then please delete the message. Thank You.
>
--
Alison Boeckmann
[EMAIL PROTECTED]
that the last line of the control stream
and data file ends with a cr-lf.
Thank you all!!
On Wed, 23 May 2007 14:01:11 +0200, "Olofsen, E. (ANST)"
<[EMAIL PROTECTED]> said:
> Dear Alison,
>
> I think the text is being read, even though an end-of-file (eof)
> con
Ribba
>
> Therapeutic Targeting in Oncology (EA3738)
> University Claude Bernard Lyon 1
> Faculty of Medicine Lyon-Sud
> 165, chemin du grand revoyet
> 69921 Oullins cedex
>
> Tel: +33 4 26 23 59 57 / +33 6 66 06 15 21
>
>
>
--
Alison Boeckmann
[EMAIL PROTE
COP.
> These need not coincide with TIMEs were you have DV values. 2. Create a
> linear interpolation of COP to be used in the $DES block.
>
> One way to do this linear interpolation is to add two columns to your
> data
> file: PTME (previous time) and PCOP (previous concentration). Then,
> compute
> SLOPE = (COP-PCOP)/(TIME-PTME)
> and use a linear interpolation of conc:
> PCOP +SLOPE*(T-PTME)
> in place of COP in computing your COEF parameter (must be in $DES block).
>
> I hope this helps,
>
> David Salinger
> RFPK, Univ. of Washington
>
>
--
Alison Boeckmann
[EMAIL PROTECTED]
Mon, 28 May 2007 13:04:22 -0700, "Mark Sale - Next Level Solutions"
<[EMAIL PROTECTED]> said:
> Alison, Thanks for this, (the answer to my question from 2 years
> ago). This will help greatly with some automated
> diagnostics/corrections in work on automated model s
>
> 4545 Horizon Hill Blvd
>
> San Antonio, TX 78229 USA
>
> [EMAIL PROTECTED]
>
> phone: 210-949-8662
>
> fax: 210-949-8219
>
> blackberry cell: 210-315-2713
>
>
>
> --
>
> Paul R. Hutson, Pharm.D.
>
> Associate Professor
>
> UW School of Pharmacy
>
> 777 Highland Avenue
>
> Madison WI 53705-
>
> Tel 608.263.2496
>
> Fax 608.265.5421
>
> Pager 608.265.7000, p7856
>
> References
>
> 1. mailto:[EMAIL PROTECTED]
--
Alison Boeckmann
[EMAIL PROTECTED]
rresponding OMEGA was not iterated, and the final
> estimate
>
> did not differ from the initial value. Below is an example control stream
>
> and the output illustrating the problem (Note, the actual model I work
> with is more complicated).
>
>
>
> Thanks in advance.
>
>
>
> Best regards,
>
> Vladimir
>
> Cut here
>
>
--
Alison Boeckmann
[EMAIL PROTECTED]
tion methods.)
On Thu, 12 Jul 2007 10:02:03 +0200, "Mats Karlsson"
<[EMAIL PROTECTED]> said:
> Dear Alison,
>
> The addition of EXP(ETA(.)) is to provide a scaling for the residual
> error magnitude. This scaling factor is 1 for the typical individual
> (ETA=0
) in the model for eta on eps.
On Thu, 12 Jul 2007 13:24:00 -0700, "Alison Boeckmann"
<[EMAIL PROTECTED]> said:
> Dear Mats, thanks for the explanation. Very helpful.
>
> You and others have said that INTERACTION is needed when there is an eta
> on EPS. Some people m
0 0 0
> 1 4 3.6 0 179.4 0 0 0
> 1 6 2.1 0 179.4 0 0 0
> 1 8 2.2 0 179.4 0 0 0
>
> Thanks
> Ganesh Mugundu
>
--
Alison Boeckmann
[EMAIL PROTECTED]
E GLU IBASE INS
> NOAPPEND ONEHEADER NOPRINT FILE=test.fit
> test.dat
> #id,time,cmt,amount,dv
> 1,0,1,.,.
> 1,0,2,.,.
> 1,0.001,1,.,.
> 1,0.002,1,1,.
> 1,0.002,2,1,.
> 1,100,1,.,.
> 1,100,2,.,.
>
> --
> Nick Holford, Dept Pharmacolo
; >EGEFF=EMXGLU*EGLU/(C50GLU+EGLU)
> > >EIEFF=EMXINS*EINS/(C50INS+EINS)
> > >E(3)=RGLU - CLGLU*(1+EIEFF)*EGLU ; GLUCOSE EQUILIBRIUM
> > >E(4)=RINS*(1+EGEFF) - CLINS*EINS ; INSULIN EQUILIBRIUM
> > > $DES
> > >DGLU=A(1)/VGLU
> > >DINS=A(2)/VINS
> > >DGEFF=EMXGLU*DGLU/(C50GLU+DGLU)
> > >DIEFF=EMXINS*DINS/(C50INS+DINS)
> > >DADT(1)=RGLU - CLGLU*(1+DIEFF)*DGLU
> > >DADT(2)=RINS*(1+DGEFF)- CLINS*DINS
> > >
> > > $ERROR
> > > GLU=A(1)/VGLU
> > > INS=A(2)/VINS
> > > IF (CMT.EQ.1)THEN
> > > Y=GLU*(1+ERR(1))+ERR(2)
> > > ENDIF
> > >
> > > IF (CMT.EQ.2)THEN
> > > Y=INS*(1+ERR(3))+ERR(4)
> > > ENDIF
> > >
> > > $TABLE ID TIME AMT CMT F1 F2 GBASE GLU IBASE INS
> > > NOAPPEND ONEHEADER NOPRINT FILE=test.fit
> > > test.dat
> > > #id,time,cmt,amount,dv
> > > 1,0,1,.,.
> > > 1,0,2,.,.
> > > 1,0.001,1,.,.
> > > 1,0.002,1,1,.
> > > 1,0.002,2,1,.
> > > 1,100,1,.,.
> > > 1,100,2,.,.
> > >
> > > --
> > > Nick Holford, Dept Pharmacology & Clinical Pharmacology
> > > University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New
> > > Zealand
> > > [EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
> > > www.health.auckland.ac.nz/pharmacology/staff/nholford
> > >
> > >
>
> --
> Nick Holford, Dept Pharmacology & Clinical Pharmacology
> University of Auckland, 85 Park Rd, Private Bag 92019, Auckland, New
> Zealand
> [EMAIL PROTECTED] tel:+64(9)373-7599x86730 fax:+64(9)373-7090
> www.health.auckland.ac.nz/pharmacology/staff/nholford
--
Alison Boeckmann
[EMAIL PROTECTED]
gt;>>RGLU=THETA(1)*EXP(ETA(1))
> >>>VGLU=THETA(2)
> >>>CLGLU=THETA(3)
> >>>EMXGLU=THETA(4)
> >>>C50GLU=THETA(5)
> >>>
> >>>;INSULIN
> >>>RINS=THETA(6)*EXP(ETA(2))
> >>>VINS=THETA
ons FUNCA, FUNCB and FUNCC. I suppose a person could study the
comments in ZSPOW1, study how it is used by PREDPP, and do something
similar in an abbreviated function. But the eta derivatives are always
going to be the hardest part.
I hope this answers all your concerns.
On Sat, 29 Sep 2007 09:50
Nick, I agree with everything you say.
I'll put the new warning on the "todo" list.
On Tue, 02 Oct 2007 09:31:45 +1300, "Nick Holford"
<[EMAIL PROTECTED]> said:
> Alison,
>
> I deliberately used the term bug/feature because it is often a question
> of p
RT NUMERICAL SLOW METHOD=1 INTERACTION LAPLACIAN POSTHOC
> SIG=6 MAX= PRINT=1 MSFO=VER1.MSF
> $COVARIANCE MATRIX=S SLOW COMPRESS PRINT=E
> $TABLE ID TIME ALPHA CLD CLE BETA V1 RZ NOPRINT FILE=VER1.TAB
> $TABLE ID TIME C01 ER=COM(1) EN CSS IPR1 IPR2 NOPRINT FILE=VER1.TAB
> $TABLE ID TIME IAGE K12 K21 K R1 IDIF NOPRINT FILE=VER1.TAB
> $SCAT CP VS IPR1 UNIT
>
--
Alison Boeckmann
[EMAIL PROTECTED]
wres <- compute.cwres(1, printToOutFile = FALSE,onlyNonZero =
> > FALSE)
>
> Error in `[.data.frame`(x, r, vars, drop = drop) :
>
> undefined columns selected
>
>
>
> When I use the COMRES number from the $PRIOR NMTRAN gives an error
> regarding the table with the wrong number of COM ARRAY .
>
>
>
> I hope someone have seen this problem before and can tell me more
> about the COMRES statement.
>
>
>
> Thank you in advance and best regards,
>
>
>
> Frederik Gorter de Vries
>
>
>
>
>
> ___
>
> Frederik Gorter de Vries
>
> LACDR / Pharmacology
>
> Gorleaus Laboratories
>
> Einsteinweg 55 2333 CC Leiden
>
> The Netherlands
>
> Tel : ++31 71 527 6142
>
> Email: [EMAIL PROTECTED]
>
>
>
>
>
--
Alison Boeckmann
[EMAIL PROTECTED]
t; >
> > When I run a basic program with NONMEM VI with G77 as compiler, I got the
> > following error message:
> >
> > AN ERROR WAS FOUND IN THE CONTROL STATEMENTS.
> >
> > 74 $TABLE: NOPRINT OR NOAPPEND OPTION REQUIRED WITH MORE THAN 8 ITEMS.
> > STOP 4 statement executed
> >
> > How to fix this, any suggestions will be highly appreciated.
> >
> > Zheng
> >
> >
>
--
Alison Boeckmann
[EMAIL PROTECTED]
o related
> questions are: a) What is the machinery that runs behind WFN for
> extracting output after nmbs and b) Xpose31() extracts only a single set
> (I think it is the first set); will downloading the newer version of
> Xpose solve this problem?
>
> Kindly advice...Mahesh
&
nd/or legally privileged. It is
> >intended solely for the use of the individual or entity named on this
> >message. If you are not the intended recipient, and have received this
> >message in error, please notify us immediately by reply e-mail and then
> >delete it from your system.
> >
> >--
--
Alison Boeckmann
[EMAIL PROTECTED]
ake you all aware of it now.
Tom and I see Mail Archive as a supplement to, not a replacement, of
Cognigen's NONMEM UsersNet Archive
http://www.cognigencorp.com/nonmem/nm
--
Alison Boeckmann
[EMAIL PROTECTED]
for cathy
--
Alison Boeckmann
[EMAIL PROTECTED]
Merck Serono does not accept liability
> for any omissions or errors in this message which may arise as a
> result of E-Mail-transmission or for damages resulting from any
> unauthorized changes of the content of this message and any attachment
> thereto. If verification is required, please request a hard-copy
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> viruses and does not accept liability for any damages caused by any
> virus transmitted therewith.
>
>
>
--
Alison Boeckmann
[EMAIL PROTECTED]
For (i) I will
> need II, SS and ADDL For (ii) I don?t need any II or SS or ADDL
> For (iii) I will need II and ADDL Kindly advice?Mahesh
> PS. I am aware that I can hard code (formatting via S-plus etc) each
> dose after the first SS dose as a separate dosing record but I
> wish to know if there is an easier method available
>
--
Alison Boeckmann
[EMAIL PROTECTED]
version 6). FOCE gave good answers always in
> both NONMEM version V and version VI. But, the question remains about
> that dependence on ordering of the THETAs with the FO method for version
> VI.
>
>
>
> Any comments? Has there been discussion on this earlier that I mi
Dear Olinto,
There has been no change to that material for years and I do not see
anything wrong.
Can you please be more specific?
-- Alison
On Sun, 20 Jan 2008 17:13:28 -0700, "Olinto Linares"
<[EMAIL PROTECTED]> said:
> I am a new user with NONMEM. Reading the NONMEM'
s (which may be
> >known outside the United States as Merck Frosst, Merck Sharp & Dohme
> >or MSD and in Japan, as Banyu - direct contact information for
> >affiliates is available at
> >http://www.merck.com/contact/contacts.html) that may be confidential,
> >
s not
> recorded because the maximum concentration and trough concentration
> varied only 3%.
>
> Could NONMEM be used for this analysis? Any comment will be highly
> appreciated.
>
> Best regards,
>
> Huali
>
>
>
--
Alison Boeckmann
[EMAIL PROTECTED]
n the data file)
>
> I am using NONMEM 6 with the Wings for NONMEM interface (v 6.1.3). Any
> suggestion to report that many parameters would be welcome.
>
> Sebastien Bihorel
> SUNY at Buffalo
--
Alison Boeckmann
[EMAIL PROTECTED]
one access an archive of all the emails of this list?
> >
> > I am looking for tools for automating the writing of models? Is it
> > included in wings? (where).
> >
> > Thanks,
> >
> > Carlos Hoyo
> > [EMAIL PROTECTED]
> >
> >
> >
> >
> >
> >
> >
--
Alison Boeckmann
[EMAIL PROTECTED]
AIL PROTECTED]> said:
> Dear Ayyappa:
>
> I think you will find the following nmusers net post useful for your
> model. Alison had kindly provided some code for a EHC model.
>
> Best regards, Sam Liao Pharmax Research
> ===
4 Dec 2008 14:06:27 -0500, "Sam Liao"
<[EMAIL PROTECTED]> said:
> Dear Alison:
> Thanks for let us know this new feature in nm 6. I have been working on
> EHC modeling for single dose as well as multiple dose pk data. I have
> some questions on how to use this new fea
to Internet e-mail for messages of this kind.
> Opinions, conclusions and other information in this message that
> pertain to the sender's employer and its products and services
> represent the opinion of the sender and do not necessarily represent
> or reflect the views and opinio
E agrees that, should this license not be renewed within
thirty (30) days after its anniversary date, LICENSEE will return all
LICENSED PRODUCTS to REGENTS and will destroy all other copies of
LICENSED PRODUCTS and any derivative works of LICENSED PRODUCTS
LICENSEE may have in his possession.
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
anyone you know of other simple workarounds to use correlations
> > instead of covariances?
> >
> > Thank you in advance, Paolo
> >
> >
>
> --
> Nick Holford, Professor Clinical Pharmacology Dept Pharmacology &
> Clinical Pharmacology University of Auckland, 85 Park Rd, Private Bag
> 92019, Auckland, New Zealand
> n.holf...@auckland.ac.nz tel:+64(9)923-6730 fax:+64(9)373-7090 mobile:
> +33 64 271-6369 (Apr 6-Jul 20 2009)
> http://www.fmhs.auckland.ac.nz/sms/pharmacology/holford
>
>
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
-
> Paolo Denti, PhD
> Post-Doctoral Fellow
> Division of Clinical Pharmacology
> Department of Medicine
> University of Cape Town
>
> K45 Old Main Building
> Groote Schuur Hospital
> Observatory, Cape Town
> 7925 South Africa
> phone: +27 21 404 7719
> fax: +27 21 448 1989
> email: paolo.de...@uct.ac.za
>
>
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
Research Group LLC < metrumrg.com >
> > > > Scientific Director, Metrum Institute < metruminstitute.org >
> > > > 2 Tunxis Rd, Suite 112, Tariffville, CT 06081 Direct:
> > > > +1.860.670.0744 Main: +1.860.735.7043 Fax: +1.860.760.6014
> > > >
> > > >
> > > >
> > > > On Dec 29, 2009, at 9:14 AM, Ethan Wu wrote:
> > > >
> > > > > Dear all,
> > > > > I am fitting a PK/PD model using FOCE INT. I do see a high
> > > >
> > > > > correlation between WRES
> > > > > I wonder could someone help me with implementation of AR
> > > > residual
> > > > > error model in NONMEM.
> > > > > Many thanks! Happy new year to all.
> > > > >
> > > > >
> > > >
> > > >
> > >
> >
> > ICON plc made the following annotations.
> > -
> > ---
> > --
> > This e-mail transmission may contain confidential or legally
> > privilegedinformation
> > that is intended only for the individual or entity named in the
> > e-mail
> > address. If you
> > are not the intended recipient, you are hereby notified that any
> > disclosure, copying,
> > distribution, or reliance upon the contents of this e-mail is strictly
> > prohibited. If
> > you have received this e-mail transmission in error, please
> > reply to the
> > sender, so that
> > ICON plc can arrange for proper delivery, and then please delete the
> > message.
> > Thank You,
> > ICON plc
> > South County Business Park
> > Leopardstown
> > Dublin 18
> > Ireland
> > Registered number: 145835
> >
> >
> > ICON plc made the following annotations.
> > -
> > -
> > This e-mail transmission may contain confidential or legally
> > privileged information
> > that is intended only for the individual or entity named in the
> > e-mail address. If you
> > are not the intended recipient, you are hereby notified that any
> > disclosure, copying,
> > distribution, or reliance upon the contents of this e-mail is
> > strictly prohibited. If
> > you have received this e-mail transmission in error, please
> > reply to the sender, so that
> > ICON plc can arrange for proper delivery, and then please delete
> > the message.
> > Thank You,
> > ICON plc
> > South County Business Park
> > Leopardstown
> > Dublin 18
> > Ireland
> > Registered number: 145835
> >
> >
>
> ICON plc made the following annotations.
> --
> This e-mail transmission may contain confidential or legally privileged
> information
> that is intended only for the individual or entity named in the e-mail
> address. If you
> are not the intended recipient, you are hereby notified that any
> disclosure, copying,
> distribution, or reliance upon the contents of this e-mail is strictly
> prohibited. If
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> ICON plc
> South County Business Park
> Leopardstown
> Dublin 18
> Ireland
> Registered number: 145835
>
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
; >
> > step13.
> > ld: in /Users/wangk/work/nm7_1.0/nm/nonmem.a, archive has no table of
> > contents
> > collect2: ld returned 1 exit status
> > No nonmem execution.
> >
> > BTW, i'm using gfortran compiler under os10.6
> >
> > Kun Wang Ph.D
> > Center for Drug Clinical Research
> > Shanghai University of Chinese Medicine
> > 1200 Cailun Road, 201203 Shanghai, China
> >
>
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
te
difference approach proposed by [1] if I can figure out how to
implement it properly.
Thanks again for your help,
Andy
[1] Petersson, Friberg, Karlsson, J. Pharmacokin. Pharmacodyn.
(2010) 37:493-506.
[1]http://gaps.cpb.ouhsc.edu/nm/58sep2496.html
From alison Fri Sep 27 10:
OC
$TABLE C ID TIME CMT EVID DV IPRE NOPRINT ONEHEADER
FILE=benzopred.tab
István Németh PhD
Biostatistician
Developmental Drug Metabolism & Pharmacokinetics
Pharmacological and Drug Safety Research
Gedeon Richter Plc
Tel: 00 36 1 505 7082
Fax: 00 36 1 889 8526
--
Alison
tand that there might be multiple situations/explanations for
this warning. I just want to get the general concepts. Thank you.
best regards,
Li li
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
HE FIRST EVENT
> > RECORD OF AN INDIVIDUAL RECORD ARE COMPUTED WITH (THE LAST ADVANCE
> > TO) AN EVENT TIME OF THE PRIOR INDIVIDUAL RECORD. "
> >
> > A related caveat is that during integration between two time points,
> > the value of data items (in the
n."
So we can ask Bob to put this on his list of changes for the next
release.
On Fri, 03 Jun 2011 03:24 +1200, "Nick Holford"
wrote:
Alison,
Thanks for these helpful explanations of some of the mysterious
behaviour of NONMEM.
The call to $DES at the time of the event record make
My comments are attached in file luann.txt
On Wed, 01 Jun 2011 17:57 -0400, "Luann Phillips"
wrote:
> Alison,
>
> Thank you for the additional information. Especially the part about $DES
> computing at the event time in a data record for output to the $TABLE. I
> wou
ations and using an empirical input function.
> >
> > My initial idea was to define a MTIME(1) corresponding to the lag-time
> > and to use MPAST(1) to set the start of the input as below.
> >
> > DADT(1)=(DOSE/V)*INPUT*MPAST(1)-K*A(1)
> >
> > However, I only end up with no input at all in the system resulting in
> > simulated DV of 0 ± residual error. The issue seems related to the
> > use MPAST with the input function but I don't know how.
> >
> > Would anyone be kind enough to point me in the right direction?
> >
> > Thanks,
> >
> > Pierre-Olivier
> >
>
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
mpast.ctl
Description: Binary data
mpast.out
Description: Binary data
>
> I am not even sure that SS would have the value of 1 during the
> calculation of the steady state solution -- although that would be a
> reasonable assumption that could be confirmed by someone such as Alison
> Boeckmann.
>
> Nick
>
> PS NONMEM calculates
(second attempt)
From: "Alison Boeckmann"
To: "Joanna Lewis"
Cc: "Nick Holford" , nmusers@globomaxnm.com
Date: Mon, 24 Oct 2011 15:38:44 -0700
Subject: Re: [NMusers] Steady state dose
My remarks are attached
lewis.ss.nmusers2.txt
On Friday, October 21, 2011
compartment when SS=2 or SS=3 given and also
comment on the information does that parameter give more than the trough
concentration measured at the clinical visit?
Regards,
Ayyappa
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
> --
> ----
> Paolo Denti, PhD
> Junior Lecturer
> Division of Clinical Pharmacology
> Department of Medicine
> University of Cape Town
>
> K45 Old Main Building
> Groote Schuur Hospital
> Observatory, Cape Town
> 7925 South Africa
> phone: +27 21 404 7719
> fax: +27 21 448 1989
> email: paolo.de...@uct.ac.za
>
>
>
> ICON plc made the following annotations.
> --
> This e-mail transmission may contain confidential or legally privileged
> information
> that is intended only for the individual or entity named in the e-mail
> address. If you
> are not the intended recipient, you are hereby notified that any
> disclosure, copying,
> distribution, or reliance upon the contents of this e-mail is strictly
> prohibited. If
> you have received this e-mail transmission in error, please reply to the
> sender, so that
> ICON plc can arrange for proper delivery, and then please delete the
> message.
> Thank You,
> ICON plc
> South County Business Park
> Leopardstown
> Dublin 18
> Ireland
> Registered number: 145835
>
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
:
ftp://nonmem.iconplc.com/Public/nonmem/transit_compartment/
The paper is:
Implementation of dose superimposition to introduce multiple doses
for a mathematical absorption model (transit compartment model)
Jun Shen, Alison Boeckmann & Andrew Vick
Journal of Pharmacokinetics and Pharmacodyna
used. If so, what has
to be change in the control stream and the dataset? I’d sincerely
appreciate it, if somebody can share with me a sample control stream to
simultaneously fit the plasma and urine data.
Kind regards,
Norman Zhou
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
.and. ABI>.1)
DELTAT=T-dosetime+(I-1)*IIVAL
IPT=DOSE*deltat**NN*EXP(-KTR*deltat)
INPT=INPT+IPT
ABI=ABS(IPT)
I=I+1
ENDDO
DADT(1)=KINPT*INPT-KTR*A(1)
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
c.s. and we will improve this for 7.3.
I suspect that somehow the size and/or complexity of abbreviated code
(hence of FSUBS) may be what is causing Intel compiler to fail.
Why this happens with 7.2 but not with earlier versions is a mystery.
Alison
On Fri, Oct 12, 2012, at 06:04 PM, Bauer
this
message is not permitted and may be unlawful.
References
1. http://www.cognigencorp.com/index.php/cognigen/resources_nonmem
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
tract
9. http://www.nature.com/psp/journal/v2/n5/full/psp201318a.html
10. http://onlinelibrary.wiley.com/doi/10./bcp.12170/abstract
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
containing an EVID data item equal to 2.
On Wed, Aug 28, 2013, at 12:53 AM, Nick Holford wrote:
Alison,
I think the problem with the on-line help arose because a relatively
inexperienced nmuser was searching through the help to find some clues
on what to do. The use of the "physiological variable ch
*EPS1+EPS2, and let the program to estimate EPS1 and EPS2?
2. What's the purpose of SIMEPS(EPS) here? From my understanding is
that if ICALL equals 4, then conduct a limited number of
Y=CP*(1+RUV_CV*EPS1)+RUV_SD*EPS2.
Thanks to you all for your kind support.
--
Xinting
--
Alison
his electronic mail message is
> intended only for the personal and confidential use of the designated
> recipient(s) named above. This message may be an attorney-client
> communication, may be protected by the work product doctrine, and may be
> subject to a protective order. As such, this message is privileged and
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> buSp9xeMeKEbrUze
>
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
in the other block.
I suggest a variable name such as RR that is never reserved under any
circumstances.
- Alison
On Thu, Mar 27, 2014, at 06:50 AM, Pavel Belo wrote:
Hello Allison,
Yes, it is solved. There was another R variable used for
approximation of normal probability densith in
$DATA session.
>>>
>>> For example:
>>>
>>> ACCEPT=c(A=1,A=2)
>>>
>>> means that record of A equals to 1 or 2 would be accepted. However,
>>> for a logic expression below:
>>>
>>> (A=1 OR A=2) AND B<100
>>>
>>> which would require A equals to 1 or 2 and in the mean time, B are
>>> less than 100.
>>>
>>> NONMEM manual VIII did not specify this type of acceptance. Could
>>> anybody please tell me how to write this kind expression using
>>> ACCEPT, or IGNORE in nonmem? Thanks a lot for your help.
>>>
>>> Best Regards
>>>
>>> --
>>> Xinting
>
>
>
--
> Xinting
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
$INPUT NO A B ID DV MDV
$DATA probe.tab (10F12.0) NOOPEN
$THETA 1
$OMEGA 1
$SIGMA .4
; This is the problem that should have $ESTIMATION or
; other tasks using the selected portion of the data set.
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
is
no point running $ESTIM till you are sure you've got the model right!
Instead, *each* problem should display items of interest $TABLE ID TIME
IND_DIA DIALYSIS TDM etc. Now you can make sure you are getting the
correct data items from the correct records.
Alison Boeckmann
On Fri, Dec 5, 2014
relying on the fact that the compartment was initally on by default.
No existing problem specification that avoided the error message
by using extra event records is incorrect. It is simply that the
data files could have been left as-is and the $MODEL statements
changed instead.
--
Alison Boeckmann
wever seems NONMEM only accepts DOSE is a positive number. If
> DOSE=0, NONMEM can't perform the fitting. Can anyone kindly give me
> some suggestions to solve this problem? Thanks a lot in advance!
>
> PTIDDVAMTtimeEVID2.126.821.13263.131.0830.16330.03639
>
>
Zheng
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
to have
> NONMEM read what is defined in $PK into $MIX?
>
> Much thanks,
>
> Mannie
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
Differential Equations in NONMEM®:
> Implementation, Application, and Comparison with Ordinary
> Differential Equations Pharmaceutical Research, Vol. 22, No. 8,
> August 2005 2005)
>
>
>
> John H. Warner, PhD, MBA
> Director, Biostatistics
> CHDI Management / CHDI Foundation
> 155 Village Boulevard, Suite 200
> Princeton, NJ, 08540
> (609) 945-9644: office
> (609) 751-7345: cell
> (609) 452-2160: fax
> john.war...@chdifoundation.org
>
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
o be computed
incorrectly and NONMEM will not reach the correct minimum, even if runs
to normal completion.
Alison
On Thu, Oct 22, 2015, at 11:56 AM, Nick Holford wrote:
> Tommy,
>
> When a variable is defined in NM-TRAN it persists to all subsequent
> records in the data set. You could
error before it gets to NONMEM or
NONMEM is generating the error message when it should not. Please send
your control stream with a fragment of the data to me and Bob Bauer, and
we can investigate the situation and fix it. For now, it appears that
the dummy $SIGMA is a good enough workaround.
Alison
data collection design
varies considerably between these individuals."
-- Alison Boeckmann
On Tue, Jan 5, 2016, at 06:03 PM, Zheng Liu wrote:
> Dear all,
>
> I recently have a data set for pk parameters fitting. The issue is
> some patients have far more measurement points than
Here iis an explanation of why the error messages were being produced
by PREDPP.
At my request, Achim send me the $MODEL statement from the control
stream. $MODEL NCOMP = 4 COMP=(G0) COMP=(G1) COMP=(G2) COMP=(G3)
Compartment 1 is the default compartment for doses and observations,
because no comp
d.ac.nz/
>
> "Declarative languages are a form of dementia -- they have no memory of
> events"
>
> Holford SD, Allegaert K, Anderson BJ, Kukanich B, Sousa AB, Steinman A,
> Pypendop, B., Mehvar, R., Giorgi, M., Holford,N.H.G. Parent-metabolite
> pharmacokinetic models - tests of assumptions and predictions. Journal of
> Pharmacology & Clinical Toxicology. 2014;2(2):1023-34.
> Holford N. Clinical pharmacology = disease progression + drug action. Br
> J Clin Pharmacol. 2015;79(1):18-27.
>
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
, at 04:18 AM, SIMON Nicolas wrote:
> Dear Alison,
>
> Perhaps I miss something but is it possible to use your code for
> interpolating WT when some WT are missing in the dataset for an
> individual?
>
> Best regards
> Nicolas
>
>
> -Message d'origine---
ds, but they are not necessarily
sequential in TIME.
Can you please send me your control stream and a fragment of the data so
I can figure out what is going on?
Alison
PS. In case you don't have the May 2015 version of guide VI PREDPP, here
is an extract:
(The guide still needs to be upd
;.
Your fix is a good one (specify both DEFDOSE and DEFOBS).
Another fix is to supply the PCMT data item in the data set, and (in my
case) set PCMT=2
This is something that can be fixed with a future version of NONMEM (its
too late for 7.4).
-- Alison
On Mon, May 1, 2017, at 09:33 AM, Bill Den
ution). The technical question was
> if there was some part of NONMEM that I didn't know related to controlling
> infusion rates in the $DES block. (Feature request to Bob and Alison: Maybe
> in NONMEM 7.5, the user could set R1 = -1 in $PK and have continuous control
> o
discrepancy in values of TAD. We will try to resolve
the discrepancy.
Alison Boeckmann
Nov 18, 2018
===
++
||
| TIME AFTER DOSE (TAD
om to report a match,
or to report a discrepancy in values of TAD. We will try to resolve
the discrepancy.
Alison Boeckmann
Dec 17, 2018
===
++
||
|
odified to use $ABBR ... REPLACE.
-- Alison
On Thu, Jan 17, 2019, at 2:27 AM, Jeroen Elassaiss-Schaap (PD-value) wrote:> Hi
Sebastien,
>
> Ok that settles it than: NMTRAN does not accept subscripts to ETA. I
> clearly misread the nm73 guide: ”Subscripts may be used with user-
> defined var
odified to use $ABBR ... REPLACE.
-- Alison
Alison Boeckmann
alisonboeckm...@fastmail.fm
uot;. So, I think it is accessible. Could you please
> tell me how to access the variable from PRED subroutine?
>
> Regards
>
> Ryota Jin
> Chiba university, Japan.
> email: ryot...@chiba-u.jp
>
>
>
--
Alison Boeckmann
alisonboeckm...@fastmail.fm
ll pass on this one. Sometimes NMTRAN may report an error on a
line near where the error is detected, not the exact line. It may
be easy to fix for this example and yet the fix may break some other
control stream.
-- Alison
On Wed, Jul 31, 2019, at 5:56 AM, Paul Hutson wrote:
> Hello, Leonid, an
6 42.6 42.6
42.6 * *
Its easy to see that this matches the original data.* *
1, 0 , 0, 100, 100, 1, 34.823, 38.212, 1.1129, 0 , 42.635, 42.635, 42.635,
42.635, 42.635, 42.635, 42.635
With WIDE option of $DATA, the table is unchanged, though FDATA is easier to
examine visually and
the format in F
there is no bug.
Thanks,
-- Alison
On Mon, Dec 9, 2019, at 12:38 AM, Mark Tepeck wrote:
> Hi Alison,
>
> Thank you so much for your comprehensive suggestion, which is definitely
> helpful. This topic is like that we are still driving a manual transmission
> car in an era of self-driv
T ADVANCE TO) AN EVENT
> TIME OF THE PRIOR INDIVIDUAL RECORD.
>
> The wording is arcane but the basic message is that, for each subject, the
> first values for DES computed entries are not what you expect.
> Despite this, NONMEM is "doing the right thing".
> I defer to
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