[NMusers] Parameter Uncertainty and Covariate effects

2016-01-11 Thread Stodtmann, Sven
Dear All, In order to account for uncertainty in estimated parameters when running a simulation, a natural approach would be running multiple simulations for different parameter vectors which are drawn from the (theoretical, asymptotic) distribution of the estimator (i.e. normal with mean THETA

[NMusers] Career Opportunities

2016-01-11 Thread Ashley Weavers
Dear all, I wanted to reach out to you today to discuss a few open positions with one of our clients, a top, global pharmaceutical company. Below is a brief description. Associate Director / Sr. Associate Director Job Description Associate Director and Sr. Associate Director for a global pharma

Re: [NMusers] Parameter Uncertainty and Covariate effects

2016-01-11 Thread Mats Karlsson
Dear Sven If you don't assume the covariance between THETA(1) and THETA(2) to be zero but use the estimated covariance value, you do let the data speak. A problem in this respect is that publications never give such values even if it of course is possible. With online access to model code and o

[NMusers] " Happy New Year ! For those of you who have not seen this announcement before the Christmas Break, here is a a 2nd sending"

2016-01-11 Thread Csajka Chantal
Dear Colleagues, We are happy to announce the 1st European Training Course on Pharmacokinetics and Pharmacodynamics of Protein Therapeutics - Principles and Pharmacometric Approaches that will be held in Lausanne, Switzerland on March 21-23, 2016. The 3-day course is a shortened version of the