Nicolas,
The suggested error model comes from the reference below. It relaxes the strong
assumption that the residual error magnitude is the same for all subjects. Such
an assumption would be valid if assay error would be the dominating error, but
it seldom is with clinical data.
Assumption te
The following workshops have been scheduled for 2016:
March 1-3 – San Francisco, California – 3-day NONMEM/PDxPoP Workshop
Location: Doubletree by Hilton San Francisco Airport, 835 Airport Boulevard,
Burlingame, CA 94010 (just 10 minutes from the airport!)
March 4 – San Francisco, California –
Dear all,
When generating a VPC for a nonparametric ($NONPARAMETRIC subroutine on) model,
I get the following error message from NONMEM 7.3.0 (installed on OSX 10.10.5,
PsN 4.4.8), which doesn't occur with creating a VPC for a "normal" parametric
model.
> “ #TERE:
> 0ERROR IN READING FILE : FI
Usually tolerance criteria for ODE solvers apply to the solution at the end of
an integration interval. In that case, there is a difference between the
solution at some time instant if it is preceded by an observation record with
MDV=1 or not. So the tolerance settings for ADVAN13 which are ok
Setting lower TOL values (as low as 2-3-4) may help as well (but it
should be done carefully as there are examples where TOL=4 solution was
different from TOL=9 solution; so if this helps, TOL should be increased
back to 7-8-9 later in the modeling process when the more stable model
is found)
Eric:
I revisited my data set and indeed I do have MDV=1 values in between values
with a positive DV due to the fact that I am generating data for
compartments where there are no observations. Oftentimes also a measured
concentration within the sampled compartment had the next time point DV
miss
Please find a press release at the site below describing the features of a new
platform aiming to advance quantitative drug development.
http://www.ddmore.eu/sites/ddmore/files/DDMoRe%20press%20release%20Dec%202015.pdf
on behalf of colleagues from the DDMoRe project
