http://www.findaphd.com/search/ProjectDetails.aspx?PJID=67654&LID=1030
Development of a precision dosing tool for simvastatin treatment in children
and adolescents with dyslipidaemias
Project Description
Dyslipidaemia is an important etiologic factor in the development of
cardiovascular disease
Hello Jeroen,
Thank you for your response. It was a practical question. I understand
the theory. What is the reason different packages show such different
results and present eigenvalues differently? What is the best way?
NONMEM demonstrated much larger max/min values but did not
Dear Pavel,
Are you using MATRIX=R when using NONMEM or the default sandwich estimator for
the covariance matrix? Most nonlinear regression packages use the equivalent
of MATRIX=R in NONMEM. You might try MATRIX=R on the $COV step and then
compare to Monolix.
Ken
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> On
NONMEM demonstrated very large differences in objective function when
variability or correlations were added or removed. Monolix demonstrated
close-to-insignificant differences. When differences in software start
to affect important conclusions it becomes interesting. It feels like
we need t
Dear All,
Could statisticians out there help me to understand the use of the
Box-Cox transformation? I found the old discussion here:
http://www.cognigencorp.com/nonmem/current/2010-June/1721.html
Specifically:
Box-Cox transformation
TVCL=THETA(1)
BXPAR=THETA(2)
PHI = EXP(ETA(1))
ETATR = (PHI
Hi Pavel,
For starters, it is simple to calculate using R:
mymat<-abs(matrix(rnorm(25^2),ncol=25))
mymat <- mymat /max(mymat)
#replace mymat with your nonmem $cov matrix
eigenval<-eigen(mymat,symm=T)$values# should be similar to nonmem
reported
cn<-max(eigenval)/min(eigenval)
eigenva
> Opening Position in Population PK and PKPD modelling, Servier, France
>
> Job description
>
> The centre of excellence of Pharmacokinetics (PEX PK) at Servier has an
> opening position for a Team Leader in Clinical Population Pharmacokinetics
> (PPK) and PKPD modelling.
>
> The candidate
Hello Pavel,
Could you share the COV matrices from Monolix and NONMEM? I have an idea of
what could be going on, but it would be good to see the matrices to check if
the hypothesis makes sense.
Best,
Matt
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Beha
