Hi Brady,
If you want to include (circadian) rhythms in the production (or elimination)
of your endogenous substance, there are also other considerations. One is that
you need to retain information about the clock time of your samples, even those
before start of therapy. The other is how to ini
Dear Brady,
If you have a model for the endogenous substance/biomarker that has a steady
state then you can just write the baseline as a function of the model
parameters. Very simple turnover example - see Rao A. BMJ Open. 2013 May
28;3(5)) IGF-1 baseline is given by Ksyn/Kout. For more compl
Postdoc Mathematical Pharmacology
The Leiden Academic Centre for Drug Research (LACDR) and AstraZeneca (AZ),
vacancy 15-169
The Leiden Academic Centre for Drug Research (LACDR) and AstraZeneca (AZ) are
looking for a:
Postdoc Mathematical Pharmacology (0.8 - 1.0 fte)
Vacancy number: 15 -169
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Dear NMUsers
I am a beginner with NONMEM. I have developed a model and want to use AGE,
WT, CRCL, SeCR and SEX as covariates on CL, V1 and V2. Can someone provide
me the step by step guidence how can I perform this Analysis by using
Pirana?
Regards
--
*Muhammad Usman*
PhD Scholar
Westfälische Wi
The department of Clinical Pharmacology Modelling and Simulation at
GlaxoSmithKline is recruiting several quantitative clinical pharmacologists, at
levels from Scientist to Senior Director. Successful candidates will have the
opportunity to work on both small molecules and biologics in therapy a
hi Muhammad,
a brief guidance on how to do a stepwise covariate search with PsN+Pirana
is given in our recent tutorial in CPT-PSP (
http://onlinelibrary.wiley.com/doi/10.1038/psp.2013.24/abstract), in which
we used the scm tool in PsN, and Pirana to generate the scm config file.
Let me know if you
