Hi Leonid,
You're right.
Best regards,
Mats
Skickat från min iPhone
25 aug 2013 kl. 02:12 skrev "lgibian...@quantpharm.com"
:
> I think there was a typo, should it be:
> IF(TIME.GT.OTIM) CCOV=OCOV+(T-OTIM)*(COV-OCOV)/(TIME-OTIM) ;CCOV is linear
> ?
> Leonid
> Original email:
> --
Dear Leonid,
I tried with your method and found the same result. The initial estimation
of the added ETA was set at 0.01, and the result showed an increase of OFV.
Please see below the $PK part of the control file for more information.
Many thanks.
Dear Bill,
Could you please explain that in a l
Hi Xinting,
When I've seen this before, it is due to the model approaching non-convergence.
Given the model that you're showing below, I'd guess that your issue is coming
from the eta on Q or V3 because it is rare to have enough data to fit true IIV
there.
Thanks,
Bill
On Aug 25, 2013, at 8
Hi Xinting,
You should be able to do it. Let's check it again this way
1. You run the model with all ETAs included, but one ETA (the one that
was excluded in the reduced model) is fixed to zero. You should be able
to reproduce your "reduced ETA" result (OF)
2. You take the same control stream, a
