RE: [NMusers] Time-varing covariate

2013-08-24 Thread Mats Karlsson
Dear Bill and Siwei, Although the thought in Bill's reply is right, I think there is an error in the code. NONMEM by default uses the present values to update from the previous time. Further, it is possible to do this interpolation on the fly in the model file without changes to the data set.

[NMusers] SAEM in NONMEM 7 question

2013-08-24 Thread Mina Nikanjam
I am running SAEM in NONMEM 7 for a 4 compartment model. At the end of each run I receive the following message, "STOCHASTIC PORTION NOT COMPLETED, REDUCED STOCHASTIC PORTION COMPLETED." I initially tried NBURN=2000 NITER=1000, then tried NBURN=5000 NITER=2000 without improvement. Is is reasonab

RE: [NMusers] Time-varing covariate

2013-08-24 Thread lgibian...@quantpharm.com
I think there was a typo, should it be: IF(TIME.GT.OTIM) CCOV=OCOV+(T-OTIM)*(COV-OCOV)/(TIME-OTIM) ;CCOV is linear ? Leonid Original email: - From: Mats Karlsson mats.karls...@farmbio.uu.se Date: Sat, 24 Aug 2013 10:02:00 +0200 To: william.s.den...@pfizer.com, ellen.siwei...@gmail