Re: [NMusers] Reducing ETAs actually decreased OFV

Hi Xinting, In a few rare cases, I've seen this happen if the model is approaching nonconvergence. In those cases, typically the RSE on one or more parameters will increase and the ratio of max to min eigenvalues will increase substantially. Are you seeing either of these? Thanks, Bill On

[NMusers] Workshop on PK and PD Modeling Biologics in Baltimore, MD

Second announcement: Leonid and Ekaterina Gibiansky (QuantPharm LLC) will present the workshop on Modeling of Biologics with Target-Mediated Disposition in Maryland (near Baltimore), September 13, 2013. The workshop provides an overview of the PK of biologics, introduces target-mediated drug

[NMusers] question in Box-Cox Transformations in K-PD model

Dear NONMEM users, I am trying to build a model to describe the drug toxicity on neuropathy. Since I am having dose and toxicity data, the K-PD model was applied in our model. The distribution of baseline is heavily left skewed. So I am also trying included the Box-cox transformation to get a accu

[NMusers] Fwd: question in Box-Cox Transformations in K-PD model

I sent wrong control stream in the previous mail. Sorry for this. Please see the control stream below. $SUBS ADVAN6 TOL=6 $MODEL NCOMP=2 COMP=(DOSE) COMP=(OBS) $PK KIN=THETA(1)*EXP(ETA(1)) BXPAR=THETA(2) PHI=EXP(ETA(2)) ETATR=(PHI**BXPAR-1)/BXPAR BASELINE=THETA(3)*

[NMusers] 3rd Annual Indiana CTSI Symposium on Disease and Therapeutic Response Modeling

*The Third Annual Indiana Clinical and Translational Sciences Institute (CTSI) Symposium * *on Disease and Therapeutic Response Modeling * *November 5 and 6, 2013* We are pleased to announce that the third annual Indiana Clinical and Translational Sciences Institute (CTSI) Symposium on Dis