Dear NMusers:
ICON Development Solutions is presenting several workshops throughout the year.
Two workshops will be hosted in Ellicott City, Maryland, April 9-11, and
September 10-12. These are 3 day workshops, first two days are
beginner/intermediate workshops, and the third day is for Monte C
Dear NMusers,
To continue the workshop advertizing section, we would like to mention
that QuantPharm LLC in collaboration with AP2POP will present the
workshop on
Modeling Biologics with Target-Mediated Disposition
on Tuesday 11 June 2013 (just before the start of the PAGE meeting).
Details
All,
I am implementing the M3 method using NONMEM7.2. My error structure is
proportional. I have two questions regarding the control stream shown below.
1. Is the control stream correct for a proportional error model?
2. Each DV has its own LOQ so I cannot give one LOQ value. I
Dear Rebecca,
I think you want to change
DUM=(LOQ-IPRED)
To
DUM=(LOQ-IPRED)/(SIG*IPRED)
BTW, with the new NONMEM version, the need to fix SIGMA to 1 is no longer
necessary as you can use SIGMA(1,1) on the right-hand side of expressions in
$ERROR
Your expression would then become
$ER
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Hi,
Thanks Mats for pointing out this new feature coming up in NONMEM 7.3.
An alternative less errorprone and computationally more efficient code
is shown below.
By defining SD in one expression it avoids errors (such as the one
Rebecca made) that are introduced by using different expression
Actually, the ability to use SIGMA(1,1) on the right side has been around since
NONMEM VI release 2.
In the case of:
PROP=THETA(1)*F ; proportional part
ADD=THETA(2) ; additive part
SD=SQRT(PROP*PROP + ADD*ADD) ; Standard deviation using proportional
This could be transposed to:
PROP=SQRT(SIGM
All,
Thank you for the prompt and thorough responses. They have been most helpful!
I really appreciate the assistance.
Rebecca
From: owner-nmus...@globomaxnm.com [owner-nmus...@globomaxnm.com] On Behalf Of
Bauer, Robert [robert.ba...@iconplc.com]
Sen
