Dear Ayappa,
This looks fine. However, with NONMEM 7.2 you can also write it as below.
Estimating SIGMA rather than fixing it and estimate a multiplicative THETA
may have speed advantages (and simpler coding for the new methods).
$ERROR
CALLFL=0
IPRED=-3
IPRED=LOG(F)
W=SIGMA(1,1) ;LOG AD
Bench to Bedside Translation of Antibody Drug Conjugates Using a Multiscale
Mechanistic PK/PD Model: A Case Study with SGN-35
By: Dhavalkumar Shah, PhD
Senior Scientist; Modeling & Simulation, Pharmacokinetics, Dynamics, and
Metabolism; Pfizer
December 11,, 2012
12:00 to 1:00 pm EST
Th
