[NMusers] Covariate modeling course in Philadelphia Oct 22-23, 2012

2012-08-13 Thread Mats Karlsson
Dear all, The Uppsala Pharmacometrics Group have over the years given a number of intermediate and advanced courses on various topics related to population PKPD modeling using NONMEM. Now we offer a new course: covariate model building. The course will provide participants with knowledge

RE: [NMusers] Intel vs AMD

2012-08-13 Thread Bob Leary
Even when using a non-Intel compiler (e.g. gnu compilers) with exactly the same compiler options and optimization levels on AMD and Intel that generates exactly the same code for both , there can be numerical differences between AMD and Intel processors. We did a study [1] on Phoenix NLME resu

RE: [NMusers] Intel vs AMD

2012-08-13 Thread Mark Sale - Next Level Solutions
Bob,  That certainly makes sense, the CPU architechs are constantly tweaking the instruction sets, even for routine things like dividing.  So, it is very unlikely that AMD and Intel both came up with exactly the same binary code for even simple math (and binary floating point instructions are alwa

Re: [NMusers] Intel vs AMD

2012-08-13 Thread Martin Johnson
Thanks for all your comments and now I understand that there could be always slight differences between different CPU/architecture. However, Would it possible that there could be differences in successful minimizations in nonmem runs. For example, for a same model, in one CPU/architecture the

Re: [NMusers] Intel vs AMD

2012-08-13 Thread Nick Holford
Martin, In my experience NONMEM internally uses a pseudo-random process to decide if convergence has been achieved even when the objective function and parameter estimates are essentially the same. As far as I know this has nothing to do with the compiler or CPU. So I do not pay much attentio

Re: [NMusers] Covariate modeling course in Philadelphia Oct 22-23, 2012

2012-08-13 Thread Stefanie Hennig
Hi Mats, To which days do we need to change PAGANZ to have this course here in Brisbane?? :-) /Stefanie On Mon, Aug 13, 2012 at 10:04 PM, Mats Karlsson wrote: > Dear all, > > ** ** > > The Uppsala Pharmacometrics Group have over the years given a number of > intermediate and advanced cour