RE: [NMusers] Error files when using multicore runs and psn ==> Fatal Error: Record SIZES is not valid

Hi Pascal This is not an error in PsN, this is a feature! NONMEM, by default, recompiles the sizes component of a run before each execution. This can take time, so there is an option to turn it off and use the default sizes (as in NONMEM versions 7.1.x and 6.x) with the "-prdefault" comman

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[NMusers] a question about unstable baseline for a soluble antibody target

Dear NMusers, I am trying to develop a TMDD model for an antibody against its soluble target in a monkey study. I have observations of the target before a single antibody IV bolus dose. My model has two compartments for antibody and target respectively. The challenging part is that the baseli