Hi Klaas and Jean,
Thanks a lot for your immediate response and input. I will definitely test
that whether having IOV on F1 will help.
But I have a more general question about IOV. Can you comment on having one
IOV in the model versus having five different IOVs across five different
occasions? Is i
Claire,
It is the traditional assumption that BOV variance does not change with
occasion (an assumption implemented with the SAME option). But it would
be quite reasonable to look for BOV variance that is different from
occasion to occasion eg. BOV in F might be relatively low soon after
star
Dear All,
We are using psn version: 3.4.2 together with NONMEM 7.2.0 on a Linux Sun
Grid Engine (SGE). When using multi-cores run on SGE, it happens sometimes
that NONMEM returns a log file where the "MONITORING OF SEARCH" starts and
nothing is reported.
Looking into the psn directory, I fou
Pascal:
I cannot help regarding having all console messages sent to the proper files in
the PSN environment, but I can assist in avoiding your present NONMEM error.
If you insert at the beginning of the control stream file
$SIZES LIM1=??
and insert a large enough value for ??, then file buffer 1
Hi Nick,
Thank you a lot for clarifying how to incorporate BOV in the model.
I tested BOV on F1 with the same option as well as variable BOVs on F1 from
different occasions. But either of them improved the fitting. Actually
according to the results from non-compartmental analysis, AUC0-inf are very
