RE: SPAM: [NMusers] Interactive Control of NONMEM runs

2012-05-25 Thread
I believe Perl Speaks NONMEM runs -> Perl which calls -> NONMEM Therefore, I think all the control-codes from the console are sent to the Perl process, not the NONMEM process. Currently, the work-around is to run NONMEM directly. However, it is theoretically possible to look at the execute

RE: SPAM: [NMusers] Interactive Control of NONMEM runs

2012-05-25 Thread Bauer, Robert
You should read the next several paragraphs in the guide, stating how you can alternatively control NONMEM if the control keys do not work in certain environments. This is done using the sig.exe program supplied with NONMEM. Robert J. Bauer, Ph.D. Vice President, Pharmacometrics, R&D ICON Deve

RE: [NMusers] Question about handling BLOQ data with mixture model

2012-05-25 Thread Martin Bergstrand
Dear Yaping, I can see that you need to make any particular consideration because you are applying a mixture model. CUMD is dependent on IPRED that in its turn is dependent on the assigned mixture. That should be enough. However, I spot what must be an error in your way of defining your m

RE: [NMusers] Question about handling BLOQ data with mixture model

2012-05-25 Thread lgibian...@quantpharm.com
Sum of probabilities should sum to 1. More standard way would be to use P(1) = 1/(1+THETA(8)+THETA(9)) P(2) = THETA(8)/(1+THETA(8)+THETA(9)) P(3) = THETA(9)/(1+THETA(8)+THETA(9)) where THETA(8) and THETA(9) are any positive numbers Regards Leonid Original Message: - From: Ma

Re: [NMusers] Question about handling BLOQ data with mixture model

2012-05-25 Thread Andy Stein
I wanted to follow up on the comments to Yaping's email.First, the three probabilities below from the original code do in fact sum to 1. P(1)=THETA(8)/100 P(2)=(1-THETA(8)/100)*THETA(9)/1000 P(3)=(1-THETA(8)/100)*(1-THETA(9)/1000) Note that: P(2) + P(3) = 1-THETA(8)/100 And thus

Re: [NMusers] Question about handling BLOQ data with mixture model

2012-05-25 Thread lgibian...@quantpharm.com
Andy, It was just "comment to the comment" where there was a discrepancy. Original values do sum to one, so this could not be the reason for the model problem. Leonid Original Message: - From: Andy Stein andy.st...@gmail.com Date: Fri, 25 May 2012 14:45:07 -0400 To: lgibian...@q