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Hi all,
I was implementing transit compartment for a absorption model for the first
time. I could not understand why the relationship between mean transit time and
transit rate is MTT=(n+1)/Ktr.
Could someone help me understand?
Thank you.
Dear Ethan,
The analytical solution for the transit model is derived for the chain of
n+1 transit compartments. You will notice that the part of analytical
solution is factorial function (n!). If the chain had a length of n transit
compartments, one would need to use factorial for (n-1). This w
Dear Ethan,
Perhaps this article is of some help:
J Pharm Sci. 1998 Jun;87(6):732-7.
Transit compartments versus gamma distribution function to model signal
transduction processes in pharmacodynamics.
Sun YN, Jusko WJ.
Department of Pharmaceutics, School of Pharmacy, State University of New
York
Dear Ethan,
My few cents...
Transit compartment model is generally used to account for
delay in the effect (e.g Cell growth;
Friberg et al JPCT 2002), (delay in placebo effect ; Mould
et al CPT 2007) or (to account for delay in absorption; Savic et al, 2007).
It is numerically stable
Dear Ethan,
I perhaps shall add that time for molecule to transition between two
neighboring compartments is equal to 1/ktr, therefore total time for
molecule to reach the absorption site will be sum of times for n+1
compartments, e.g. (n+1/ktr).
Rada
From: owner-nmus...@globomaxnm.co
