[NMusers] 12th Fisher/Shafer NONMEM Workshop with PLT Tools

Dear Colleagues: The 12th Fisher/Shafer NONMEM Workshop with PLT Tools will be held in Bethesda, Maryland from Wednesday, November 3rd, 2010 through Saturday, November 6th, 2010. You can find the course description and registration details at www.nonmemcourse.com.

[NMusers] EOP2A experience?

Dear All, I am interested on the FDA guidance about End of Phase 2 A (EOP2A) meetings. Some of you certainly have participated into the preparation or have attended such meeting (during the pilot phase or after) and have real life experience. If so, it would be much apreciated if you could sha

[NMusers] Translate ALAG1 and D1 in ADVAN2 to differential equations

Dear NMusers, I'm using ADVAN2 to model the PK of a drug. To best fit the profile, the model includes ALAG1 and D1. For the next step, the ADVAN2 needs to be translated into differential equation to include a PD compartment. How should I write the differential equation for ALAG1 and D1? As y

RE: [NMusers] Translate ALAG1 and D1 in ADVAN2 to differential equations

Shelley, You would use ADVAN6, ADVAN8, or ADVAN13, and code the differential equations explicitly in the $DES block. See the included CONTROL7 in the NONMEM examples. Also note, you have an interesting error structure. Usually I have lognormal errors, that is KA = THETA(x)*EXP(ETA(x)) You h

Re: [NMusers] Translate ALAG1 and D1 in ADVAN2 to differential equations

Xiao Hu, Part 1) NONMEM handles the input of all doses automatically via the dataset structure. Therefore, generally there is no need to initialize compartments or to code infusion rates in the $DES block. An exception to this rule is when you are dosing or modeling endogenous substances. Ass

Re: [NMusers] Translate ALAG1 and D1 in ADVAN2 to differential equations

Dear Luann, Andreas and others, Both parts are very clear to me now. Thank you very much! My problem was, when I tried to simulate the differential equation model with parameters from ADVAN2, it did not work. The error message is listed below. This was not an issue during the model switch w

Re: [NMusers] EOP2A experience?

Hi Pascal I'm not sure if you are aware of the recent AAPS webinar on EOP2A conducted by Joga Gobburu but you may find it useful: http://mediaserver.aapspharmaceutica.com/meetings/webinars/archives.pdf Regards Masoud On 10 August 2010 16:32, wrote: > > Dear All, > > I am interested on the FDA