Coen suggests using # as the ignore character and proposes to add
IGNORE=# to the $DATA record.
In fact things can be simpler than that. The default value for IGNORE is
# so if you use # in your data file you dont have to waste time adding
IGNORE=# :-)
I dont know where this strange idea of
Hi Nick, Coen, all,
I would go one step further and suggest IGNORE=@ instead of IGNORE=# (the
same as leaving out the IGNORE option). This has the advantage of ignoring
all lines starting with alphabetic characters in the data file, such as
those belonging to column headings, as well as I, C, a
Dear all
I need to reset a single compartment in a model of several cmts, without
resetting the whole system for the
subject (which EVID=4 would do). Is there a *smart* way to do this?
Thanks,
Thomas
Thomas Klitgaard
Principal Scientist
Biomodelling
Novo Nordisk A/S
Krog
Is anyone aware of any papers or abstracts using computer-assisted trial design
that incorporates a pharmacoeconomic component to the simulation? Or any pop
pharmacokinetic-pharmacodynamic papers that include the same?
Thanks
Pete bonate
Peter L. Bonate, PhD, FCP
Genzyme Corporation
Senior Di
Hi Mark,
Very interesting point. In general, your logic about why the covariance
step doesn't matter in the bootstrapping case makes sense to me.
However, I have some questions about why such a conclusion was reached.
My questions are: 1. how many data sets are bootstrapped, 2. among them,
what's
Thomas,
Two solutions (their smart scale is up to you to judge ;-):
1 - rewrite the model so you don't need the changepoint (best approach IMHO)
2 - I guess you could switch the model to a different differential equation
instead
e.g.
CHNG = KIN*(1-EFF) - (A(3)*SLCT+A(4)*(1-SLCT))*KOUT
Pete,
The best paper I know is by Hughes et al - see below with abstract
Hughes DA, Walley T. Economic evaluations during early (phase II) drug
development: a role for clinical trial simulations? Pharmacoeconomics.
2001;19(11):1069-77.
Abstract
Faced with increasing demands on demonstrating c
From the NM help for CMT data item:
Other-Type Event:
A positive value of CMT specifies a compartment to be turned on.
A negative value of CMT specifies a compartment to be turned off.
So my guess is that
EVID CMT
2 -3
2 3
Should reset this particular compartment 3
Yaming, For details, I'd refer you to the abstracts, I've never published this. But, whenever I do a bootstrap I look at whether the samples that had a successful covariance step are different (in mean or variability), just for my own interest. They never have been different, I'd guess I've loo
I have not tried it either, but, I think this would not reset the amounts in
these compartments. I believe it would retain the value when turned off until
turned back on.
-Original Message-
From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Leonid Gi
Dear Thomas,
Compartments can be turned on and off by specifying extra events (EVID=2) in
the data set. To turn off CMT N use CMT column equal to N, to turn it on
use N in CMT column.
Best regards,
Mats
Mats Karlsson, PhD
Professor of Pharmacometrics
Dept of Pharmaceutical Bioscienc
Dear Dr. Bachman,
My thinking was that the amount in these compartments is "emptied" i.e. set to
zero and turned off (and hence the CMT needs to turned back on again). There
are some nice postings by Drs. Karlsson and Gibiansky on how to "empty" the
urine compartment when modeling urine sample c
One person who tests a hypothesis is worth 10 who speculate on the outcome!
Thanks to Leonid, Dick Brundage (who quoted chapter & verse from the NONMEM
Manual), and to Mahesh. I stand corrected.
Bill
-Original Message-
From: Leonid Gibiansky [mailto:lgibian...@quantpharm.com]
Sent: T
A clinical utility index (CUI), as described recently by Ouellet et al.
Clinical Pharmacology & Therapeutics (2009); 85, 3, 277?282 as well as by
others elsewhere, is amenable to being used as a pharmacoeconomic vehicle.
Typically the CUI is derived in terms of patient benefit:risk, but could
Hi,
I can tell you from real experience that CMT=negative resets that
compartment to zero and turns the CMT off i.e. it will not accumulate
anything. A subsequent CMT=positive will turn the CMT on i.e. it will
then start to accumulate.
This is a very helpful feature in NONMEM for those interes
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