Hi Jing,
Testing covariates on dispostition of your long acting injectable all depends
on the pharmaceutics. E.g., if you have an intramuscularly injection of a
nano-suspension, you might want to consider a zero order process for the
release of the drug in the systemic circulation and see wheth
Jing,
I think this is a strategy should be guided by the key questions you are
trying to address with your model. If your goal is simply to best
approximate the shape of the profile in existing individuals, the strategy
you employ could be vastly different than if the next step would be to
simulat
