Re: [NMusers] Steady-state (SS) and $DES veeeery slow

2016-05-20 Thread Paolo Denti
Dear Bob and Alison, thank you for the prompt responses. So it seems like the same TOL is used both for the precision of the differential equations and the stopping criterion of SS, correct? Bob I am not sure I feel brave/bold enough to recode my own version of NONMEM, but I can try. The quest

Re: [NMusers] Steady-state (SS) and $DES veeeery slow

2016-05-19 Thread Alison Boeckmann
Dear Paolo, As Bob explained, ZSPOW uses the  TOL defined by the user in the $SUBROUTINES record to determine precision.  ADVAN9 and ADVAN13 also use a separate absolute tolerance ATOL, which is by default set to 12, but you can modify it with $EST … ATOL= , and see if it affects the precision of

RE: [NMusers] Steady-state (SS) and $DES veeeery slow

2016-05-18 Thread Bauer, Robert
Paolo: From what I can tell in scanning the code of ..\pr\SS13.f90, the TOL setting on the $SUBROUTINES record appears to determine the precision of the steady state condition. You can change the TOL value, or, if you wish the SS precision to differ from the ODE evaluation precision, you can mo