Dears Leonid and Saeheum,
First of all, thank you for your suggestions, they are very useful and
cleared up some queries I had.
Leonid, regarding your question about measurement of free or total
ligand concentration, in this study we only measured the free ligand
concentration.
Thank so much,
Reg
The code will work as written (if you add ENDIF after TVVM = THETA (6),
and define all parameters CL, V1, Q, V2, KINT, ...) but mechanistically,
this is not a good idea to have two models for two dose levels. You may
want to try QSS model with non-constant Rtot (MM model is usually good
when R
Generally speaking, the portion which undergoes saturatable clearance due
to ligand or receptor engagement will be negligible at high concentrations.
Therefore, it is recommend to use one saturable equation without needs of
dose dependent “IF .. THEN … ENDIF “ Statement
The followings are some
