Dear Anna,
Just to answer quickly on the question directed to me: Yes, you understood it
correctly.
To implement this in practice, since your NONMEM dataset only includes one
level for the covariate (all subjects have the same covariate value), you will
need to make a small addition to the SCM
Dear Jakob and Mats,
Thank you very much for your kind answers.
My questions were general, for different applications. After reading the
article by Gisleskog at al. (in particular, the last part of the
discussion), I thought it was possible to build a “Model without covariate”
with $PRIOR and the
Hi Anna,
That you want to explore covariate relationships on a parameter suggests that
you believe your data contain plenty of information about the parameter.
Therefore do you really need to use a prior on the parameter(s) in question? A
little more info around what your “base” model is and wh
Dear Anna,
The times I have used SCM in combination with a frequentist prior, it has been
only to test if a new population is different (i.e. the data used to generate
the prior were all of a different population, e.g. healthy volunteers and other
indications than the currently-investigated pop
