rs@globomaxnm.com
Subject: Re: [NMusers] VPC with Mixture Model
Hi,
I realized after I sent the comment below about mixture model
**simulations** that Mats was no doubt referring to the problem of
separating the two sub-populations in the **observed** data using
MIXEST. This will of course be p
Sweden
phone: +46 18 4714105
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-Original Message-
From: Leonid Gibiansky [mailto:lgibian...@quantpharm.com] Sent:
Tuesday, April 14, 2009 9:06 PM
To: Mats Karlsson
Cc: 'Satyendra Suryawanshi'; nmusers@globomaxnm.com
Subject: Re: [NMusers] VPC with Mixture Mod
sala Sweden
> phone: +46 18 4714105
> fax: +46 18 471 4003
>
>
> -Original Message-
> From: Leonid Gibiansky [mailto:lgibian...@quantpharm.com]
> Sent: Tuesday, April 14, 2009 9:06 PM
> To: Mats Karlsson
> Cc: 'Satyendra Suryawanshi'; nmusers@globomaxnm.c
.com]
Sent: Tuesday, April 14, 2009 9:06 PM
To: Mats Karlsson
Cc: 'Satyendra Suryawanshi'; nmusers@globomaxnm.com
Subject: Re: [NMusers] VPC with Mixture Model
Hi Mats,
Could you elaborate why you would not stratify based on the
subpopulations? It seems perfectly reasonable for
om: Leonid Gibiansky [mailto:lgibian...@quantpharm.com]
Sent: Tuesday, April 14, 2009 9:06 PM
To: Mats Karlsson
Cc: 'Satyendra Suryawanshi'; nmusers@globomaxnm.com
Subject: Re: [NMusers] VPC with Mixture Model
Hi Mats,
Could you elaborate why you would not stratify based on the
subp
Hi Mats,
Could you elaborate why you would not stratify based on the
subpopulations? It seems perfectly reasonable for me to simulate from
the model (including random assignment of subpopulations), and then
compare "apples to apples": observed subpopulation versus simulated
subpopulations. In
Dear Satyendra,
Interesting question. I don't think there is much written about this, but I
may be wrong. What I would not do is to try to stratify based on estimated
subpopulation allocation ("EST"). Rather I would use the same VPCs as if
there had been no mixture model. Possibly what you coul
