-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On
Behalf Of Toufigh Gordi
Sent: 05 March 2012 22:45
To: Wang, Xiaofeng; 'nmusers@globomaxnm.com'
Subject: Re: [NMusers] time-dependent clearance model
Whenever I start a modeling process, my first objective is to get the
struct
; To: Wang, Xiaofeng; 'nmusers@globomaxnm.com'
> Subject: Re: [NMusers] time-dependent clearance model
>
> Xiaofeng,
>
> It always amazes me how many parameters we try to estimate based on the
> limited amount of data available. This is specially the case when a rather
katerina
Gibiansky [egibian...@quantpharm.com]
Sent: Sunday, March 04, 2012 8:53 PM
To: 'nmusers@globomaxnm.com'
Subject: Re: [NMusers] time-dependent clearance model
Xiaofeng,
Such a large difference suggests you may have a problem with units: check AMT,
DV, and the parameter S2 for consisten
Gibiansky [egibian...@quantpharm.com]
> Sent: Sunday, March 04, 2012 8:53 PM
> To: 'nmusers@globomaxnm.com'
> Subject: Re: [NMusers] time-dependent clearance model
>
> Xiaofeng,
>
> Such a large difference suggests you may have a problem with units: check AMT,
>
sers] time-dependent clearance model
Xiaofeng,
Such a large difference suggests you may have a problem with units: check AMT,
DV, and the parameter S2 for consistency.
A couple of other points:
- If the full induction is expected by day 7, and you only have data on day 1
and after day 7, you may not
Xiaofeng,
Such a large difference suggests you may have a problem with units:
check AMT, DV, and the parameter S2 for consistency.
A couple of other points:
- If the full induction is expected by day 7, and you only have data
on day 1 and after day 7, you may not
, Xiaofeng
Subject: Re: [NMusers] time-dependent clearance model
How do you know the initial guess of KIN ? Right now it is 0.02 which will mean
~40-50hr for CL half life (so to imagine) you think it's reasonable for CL to
drop by that much in 50hrs ? You can possibly try different initial gu
Dear nmusers,
I have a drug with clearance autoinduction. I have sparse data(three
observations on day 1, two between day 7 and 14, and one on day 28). I am
trying to run a time-dependent clearance model. I tried FO and FOCEI, but I
always got unreasonable estimate for the initial clearance (C
