RE: [NMusers] bootstrap

2019-05-11 Thread Nick Holford
turday, 11 May 2019 4:33 PM To: Bill Denney Cc: nmusers Subject: Re: [NMusers] bootstrap Dear Nick and Bill, Thank you for your answers, and please apologize me for din´t give you information about my model. I share with you part of my code as well as some results. My model corresponds t

Re: [NMusers] bootstrap

2019-05-11 Thread Niurys.CS
27;t help, giving more info will help. (What tool are you using > for bootstrap? What command line are you running? Can you share the model > and a snippet of the data?) > > Thanks, > > Bill > > -Original Message- > From: owner-nmus...@globomaxnm.com On Beh

RE: [NMusers] bootstrap

2019-05-10 Thread Bill Denney
?) Thanks, Bill -Original Message- From: owner-nmus...@globomaxnm.com On Behalf Of Niurys.CS Sent: Friday, May 10, 2019 12:17 PM To: nmusers Subject: [NMusers] bootstrap Dear nmusers, I have a big doubt. When I used the bootstrap to evaluate my model, I had some bugs. In my code I

[NMusers] bootstrap

2019-05-10 Thread Niurys.CS
Dear nmusers, I have a big doubt. When I used the bootstrap to evaluate my model, I had some bugs. In my code I use IGNORE statements based on FLAGS for some outliers. I don't know if I remove these IGNORE statements, the bootstrap will run well. Can you give me some suggestions??? Regards

RE: [NMusers] Bootstrap, re-using inital model run results

2013-02-14 Thread pascal . girard
, PhD pascal.gir...@merckgroup.com Head of Modeling & Simulation - Oncology Global Exploratory Medicine Merck Serono S.A. · Geneva Tel: +41.22.414.3549 Cell: +41.79.508.7898 From: To: "Mats Karlsson" Cc: , Date: 14/02/2013 10:33 Subject: RE: [NMusers] Boots

RE: [NMusers] Bootstrap, re-using inital model run results

2013-02-14 Thread Mats Karlsson
4714003 From: anubha_gu...@eisai.net [mailto:anubha_gu...@eisai.net] Sent: 14 February 2013 10:07 To: Mats Karlsson Cc: jos.lomme...@merck.com; nmusers@globomaxnm.com Subject: RE: [NMusers] Bootstrap, re-using inital model run results Dear Mats My question is more related to boot

RE: [NMusers] Bootstrap, re-using inital model run results

2013-02-14 Thread Anubha_Gupta
Date: 14/02/2013 08:50 Subject:RE: [NMusers] Bootstrap, re-

RE: [NMusers] Bootstrap, re-using inital model run results

2013-02-14 Thread Mats Karlsson
nt: 14 February 2013 08:29 To: nmusers@globomaxnm.com Subject: [NMusers] Bootstrap, re-using inital model run results Hi I would like to ask to NONMEM community whether it is possible to re-use the results of a nonmem model run when starting bootstrapping. As I understand, a bootstrap run usi

[NMusers] Bootstrap, re-using inital model run results

2013-02-14 Thread Lommerse, JPM (Jos)
Hi I would like to ask to NONMEM community whether it is possible to re-use the results of a nonmem model run when starting bootstrapping. As I understand, a bootstrap run using PsN starts with a single calculation of the model of interest and data set as is. Once this initial model run has comp

RE: AW: [NMusers] Bootstrap histograms in R

2012-10-08 Thread Attkins, Neil
Hi Mike, Great, many thanks for your suggestions, I will definitely try them out. Many thanks Neil From: Smith, Mike K [mailto:mike.k.sm...@pfizer.com] Sent: 06 October 2012 11:22 To: 'sebastian.frec...@uk-koeln.de'; Attkins, Neil; 'nmusers@globomaxnm.com' Subject: Re: AW:

Re: AW: [NMusers] Bootstrap histograms in R

2012-10-06 Thread Smith, Mike K
echen, Dr. Sebastian [mailto:sebastian.frec...@uk-koeln.de] Sent: Saturday, October 06, 2012 05:35 AM To: 'Attkins, Neil' ; nmusers@globomaxnm.com Subject: AW: [NMusers] Bootstrap histograms in R Hey Neil If you would like to save your graphics in a pdf you could also add the following

AW: [NMusers] Bootstrap histograms in R

2012-10-06 Thread Frechen, Dr. Sebastian
us...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] Im Auftrag von Attkins, Neil Gesendet: Freitag, 5. Oktober 2012 16:33 An: Tremblay, Pierre-Olivier; nmusers@globomaxnm.com Betreff: RE: [NMusers] Bootstrap histograms in R Hi Pierre-Olivier, Thank you for your suggestion that

RE: [NMusers] Bootstrap histograms in R

2012-10-05 Thread Attkins, Neil
Hi Pierre-Olivier, Thank you for your suggestion that has worked perfectly ;-) Many thanks Neil From: Tremblay, Pierre-Olivier [mailto:potremb...@pharmanet-i3.com] Sent: 05 October 2012 15:20 To: Attkins, Neil Subject: RE: [NMusers] Bootstrap histograms in R Hi Neil, We don't have the

[NMusers] Bootstrap histograms in R

2012-10-05 Thread Attkins, Neil
Hi I have just run a bootstrap analysis on my final Pop PK model using NONMEM 7.2 with PDx-Pop 5. My model has 7 Thetas in it and when I come to evaluate the output from the bootstrap in R the Theta histograms are plotted in a 3x2 matrix in an R window, and the plot for Theta 7 seems to overwri

RE: [NMusers] Bootstrap in combination with PRIOR?

2011-12-26 Thread Perez Ruixo, Juan Jose
. -Original Message- From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Leonid Gibiansky Sent: jueves, 22 de diciembre de 2011 7:08 To: Brogren Jacob Cc: nmusers@globomaxnm.com Subject: Re: [NMusers] Bootstrap in combination with PRIOR? Jacob, Bootstrap

Re: [NMusers] Bootstrap in combination with PRIOR?

2011-12-22 Thread Leonid Gibiansky
Jacob, Bootstrap procedure vary only the new data. The information in priors is still the same. Therefore, results will be as dependent on the priors as the parameter estimates of the final model. When the priors are strong (informative) it would require a lot of new data to move the parameter

[NMusers] Bootstrap in combination with PRIOR?

2011-12-22 Thread Brogren Jacob
Dear nmusers, Merry Holiday! (you may change the variable 'Holiday' to an arbitrary value) First, accept my humble excuse - I can't share any code for this example. I'm assessing a model where $PRIOR is used to stabilize the fit of an 'old' model to sparse data using NONMEM. It seems to be the

Re: [NMusers] Bootstrap analysis

2009-04-21 Thread Leonid Gibiansky
I do not think that bootstrap mean is a useful statistics. Median of the bootstrap distribution could/should be compared with the final-model point estimates. Precision of the parameter estimates can be evaluated as a 95% confidence interval defined as an interval between 2.5 and 97.5 percentil

Re: [NMusers] Bootstrap analysis

2009-04-21 Thread Nick Holford
Varsha, Congratulations on discovering how to use a bootstrap to evaluate the distribution of your model parameter estimates. The bootstrap mean is probably a more robust estimate of the true value of the parameter than the value estimated from the original data. I prefer to report the boots

[NMusers] Bootstrap analysis

2009-04-21 Thread Varsha Mehta
Group: I have bootstrap analysis (my first) parameter estimates and model parameters. The PDxPOP/NONMEM manual I have does not provide any guidance as to how I can statistically compare these two (or do I need to?). I also have histograms for the thetas in bootstrap analysis. I can make some vi