RE: [NMusers] Splitting the residual error

2016-05-13 Thread Mats Karlsson
tephen Duffull; Andre Jackson; nmusers Subject: Re: [NMusers] Splitting the residual error Hi Steve and Andre, No, nothing fancy, I did not even estimate the time of the switch. Something like this: ITAD=1 IF(TAD.LE.4) ITAD=THETA(10) Y=F + (F*ITAD*ERR(1)+ERR(2)) ITAD can also include differen

Re: [NMusers] Splitting the residual error

2016-05-13 Thread Ekaterina Gibiansky
Gibiansky *Sent:* Saturday, 14 May 2016 2:07 a.m. *To:* Jonathan Moss ; nmusers@globomaxnm.com *Subject:* Re: [NMusers] Splitting the residual error Dear Jon, We routinely use separate residual errors during absorption and later (say, a larger error in the first X hours), although I do not remember

Re: [NMusers] Splitting the residual error

2016-05-13 Thread Ekaterina Gibiansky
s/> *From:*owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] *On Behalf Of *Jonathan Moss *Sent:* Friday, May 13, 2016 11:37 AM *To:* nmusers@globomaxnm.com *Subject:* [NMusers] Splitting the residual error Dear all, I would like to share with you and get people’s opinions on a recent iss

RE: [NMusers] Splitting the residual error

2016-05-13 Thread Mats Karlsson
r-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Jonathan Moss Sent: Friday, May 13, 2016 11:37 AM To: nmusers@globomaxnm.com Subject: [NMusers] Splitting the residual error Dear all, I would like to share with you and get people's opinions on a recent issue I

[NMusers] Splitting the residual error

2016-05-13 Thread Jonathan Moss
Dear all, I would like to share with you and get people's opinions on a recent issue I had. I have a data set of 46 patients, orally dosed, with very dense sampling during absorption (0.25h, 0.5h, 0.75h, 1h, 1.5h, 2h, 3h, 4h, 6h, 8h, 12h, 24h, 36h), Cmax at around 4 hours. During modelling, I