Ann
Try ADVAN6 or ADVAN8 or ADVAN13 .
Also, TOL=3 is too small. Increase it to 6-7 or even 9, and also change
to NSIG=3 SIGL=9 ($EST step, as recommended in the guide).
Also, at least initially, I would remove ETAs from the third compartment
and from one of the parameters (Q2 or V2) of the seco
Dear All
I'm trying to evaluate a transit model approach in an attempt to better
describe early drug concentrations following intravenous injection (1 minute
and 10 minute infusions) of a sedative-hypnotic drug. However, every
minimisation attempt is terminated due to rounding errors (E=134).
