Re: [NMusers] Question about interoccation variability

ox 591 > 75124 Uppsala > > Phone: +46 18 4714105 > Fax + 46 18 4714003 > > From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On > Behalf Of Xu, Claire > Sent: 12 July 2012 15:11 > Cc: nmusers > Subject: Re: [NMusers] Question about interoccatio

RE: [NMusers] Question about interoccation variability

r-nmus...@globomaxnm.com] On Behalf Of Xu, Claire Sent: 12 July 2012 15:11 Cc: nmusers Subject: Re: [NMusers] Question about interoccation variability Hi Nick, Thanks for your helpful comment. I will test BOV + BSV on my absorption model parameters first. Sorry for my typo. I meant neither

Re: [NMusers] Question about interoccation variability

Hi Nick, Thanks for your helpful comment. I will test BOV + BSV on my absorption model parameters first. Sorry for my typo. I meant neither of the models improved the fit. Thanks again for your help. Best, Claire On Thu, Jul 12, 2012 at 8:07 AM, Nick Holford wrote: > Claire, > > See below: > > >

Re: [NMusers] Question about interoccation variability

Claire, See below: On 11/07/2012 9:45 p.m., Xu, Claire wrote: Hi Nick, Thank you a lot for clarifying how to incorporate BOV in the model. I tested BOV on F1 with the same option as well as variable BOVs on F1 from different occasions. But either of them improved the fitting. I am not sure

Re: [NMusers] Question about interoccation variability

Hi Nick, Thank you a lot for clarifying how to incorporate BOV in the model. I tested BOV on F1 with the same option as well as variable BOVs on F1 from different occasions. But either of them improved the fitting. Actually according to the results from non-compartmental analysis, AUC0-inf are very

Re: [NMusers] Question about interoccation variability

Claire, It is the traditional assumption that BOV variance does not change with occasion (an assumption implemented with the SAME option). But it would be quite reasonable to look for BOV variance that is different from occasion to occasion eg. BOV in F might be relatively low soon after star

Re: [NMusers] Question about interoccation variability

Hi Klaas and Jean, Thanks a lot for your immediate response and input. I will definitely test that whether having IOV on F1 will help. But I have a more general question about IOV. Can you comment on having one IOV in the model versus having five different IOVs across five different occasions? Is i

Re: [NMusers] Question about interoccation variability

I think I would try IOV on F1 first before putting it on KA like Jean suggested but above all I think there is an essential element missing in your code. IOV is variability between occasions on top of inter individual variability. So do something like: F1=1 F1=THETA(1)*EXP(ETA(6)+BOVKA) $OMEGA

RE: [NMusers] Question about interoccation variability

...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Xu, Claire Sent: Tuesday, July 10, 2012 4:46 PM To: nmusers@globomaxnm.com Subject: [NMusers] Question about interoccation variability Hi, everyone: I am trying to develop a pop PK model for a compound with a large variability in

[NMusers] Question about interoccation variability

Hi, everyone: I am trying to develop a pop PK model for a compound with a large variability in absorption. I have difficulty in fitting the absorption phase, especially the Cmax. Some of the subjects are underpredicted while some subjects are overpredicted. Since the study is a four-way cross-over