RE: [NMusers] M3 method and multiple LOQ values

2013-03-07 Thread Rebecca N. Burns
] Sent: Thursday, March 07, 2013 7:43 PM To: Nick Holford; nmusers Subject: RE: [NMusers] M3 method and multiple LOQ values Actually, the ability to use SIGMA(1,1) on the right side has been around since NONMEM VI release 2. In the case of: PROP=THETA(1)*F ; proportional part ADD=THETA(2) ; additive

RE: [NMusers] M3 method and multiple LOQ values

2013-03-07 Thread Bauer, Robert
0769 Email: robert.ba...@iconplc.com Web: www.iconplc.com -Original Message- From: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Nick Holford Sent: Thursday, March 07, 2013 5:59 PM To: nmusers Subject: Re: [NMusers] M3 method and multiple LOQ values Hi, Th

Re: [NMusers] M3 method and multiple LOQ values

2013-03-07 Thread Nick Holford
-nmus...@globomaxnm.com] *On Behalf Of *Rebecca N. Burns *Sent:* 07 March 2013 17:46 *To:* nmusers@globomaxnm.com *Subject:* [NMusers] M3 method and multiple LOQ values All, I am implementing the M3 method using NONMEM7.2. My error structure is proportional. I have two questions regarding the control s

RE: [NMusers] M3 method and multiple LOQ values

2013-03-07 Thread Mats Karlsson
@globomaxnm.com Subject: [NMusers] M3 method and multiple LOQ values All, I am implementing the M3 method using NONMEM7.2. My error structure is proportional. I have two questions regarding the control stream shown below. 1. Is the control stream correct for a proportional error model

[NMusers] M3 method and multiple LOQ values

2013-03-07 Thread Rebecca N. Burns
All, I am implementing the M3 method using NONMEM7.2. My error structure is proportional. I have two questions regarding the control stream shown below. 1. Is the control stream correct for a proportional error model? 2. Each DV has its own LOQ so I cannot give one LOQ value. I