RE: [NMusers] Error in LSODA: Code -5

2015-12-11 Thread Andre Jackson
missing so it was set to MDV=1. -Original Message- From: e.olof...@lumc.nl [mailto:e.olof...@lumc.nl] Sent: Friday, December 11, 2015 9:40 AM To: jacksonan1...@gmail.com; lgibian...@quantpharm.com; nmusers@globomaxnm.com Subject: RE: [NMusers] Error in LSODA: Code -5 Usually tolerance

Re: [NMusers] Error in LSODA: Code -5

2015-12-11 Thread Leonid Gibiansky
lf of Andre Jackson [jacksonan1...@gmail.com] Sent: Thursday, December 10, 2015 9:22 PM To: 'Leonid Gibiansky'; nmusers@globomaxnm.com Subject: RE: [NMusers] Error in LSODA: Code -5 Leonid: I tried the first suggestion by getting rid of some of the data that was deficient (i.e., subjects w

RE: [NMusers] Error in LSODA: Code -5

2015-12-11 Thread E.Olofsen
us...@globomaxnm.com [owner-nmus...@globomaxnm.com] on behalf of Andre Jackson [jacksonan1...@gmail.com] Sent: Thursday, December 10, 2015 9:22 PM To: 'Leonid Gibiansky'; nmusers@globomaxnm.com Subject: RE: [NMusers] Error in LSODA: Code -5 Leonid: I tried the first suggestion by getting

RE: [NMusers] Error in LSODA: Code -5

2015-12-11 Thread Mats Karlsson
] On Behalf Of SIMON Nicolas Sent: Friday, December 11, 2015 8:24 AM To: Andre Jackson; 'Leonid Gibiansky'; nmusers@globomaxnm.com Subject: RE: [NMusers] Error in LSODA: Code -5 Leonid, You suggest the following residual model: Y=IPRED*(1+W*EXP(ETA())*EPS()) Could you give more informa

RE: [NMusers] Error in LSODA: Code -5

2015-12-10 Thread SIMON Nicolas
di 10 décembre 2015 21:22 À : 'Leonid Gibiansky'; nmusers@globomaxnm.com Objet : RE: [NMusers] Error in LSODA: Code -5 Leonid: I tried the first suggestion by getting rid of some of the data that was deficient (i.e., subjects with less than 8 concentrations over the 30 hr. sampling period)

RE: [NMusers] Error in LSODA: Code -5

2015-12-10 Thread Andre Jackson
the analysis. Thanks for your input. Andre -Original Message- From: Leonid Gibiansky [mailto:lgibian...@quantpharm.com] Sent: Thursday, December 10, 2015 9:59 AM To: Andre Jackson; nmusers@globomaxnm.com Subject: Re: [NMusers] Error in LSODA: Code -5 Usually this error message is not

Re: [NMusers] Error in LSODA: Code -5

2015-12-10 Thread Leonid Gibiansky
Usually this error message is not informative: it just tells you that something is wrong with the model. It can be fixed by (in the order of importance) - cleaning the data (look on concentration-time plots to remove obvious outliers), - starting with the better initial parameter values (e.g., y

[NMusers] Error in LSODA: Code -5

2015-12-10 Thread Andre Jackson
I have run a control stream that runs okay following MU modeling with the mean data to establish the best structural model using NM7 with ADVAN 13 TRANS1 TOL=6. However when I attempt to run the model in a population mode with even one eta on a MU I get the following error. OCCURS DURING SEAR