: [NMusers] Autoinduction model - An increased
clearance(day 1- 14)
Dear Rob ter Heine,
I am working with Efavirenz, I working with 66 patients, 924 data
points, intense on day 1 and 14 and a trough con in between the two
weeks.
I looked into the Physiological model presented by Dr. Karlsson earlier
xnm.com [mailto:owner-nmus...@globomaxnm.com]
> *On Behalf Of *Shankar Lanke
> *Sent:* Monday, March 28, 2011 4:51 PM
> *To:* r.ter.he...@meandermc.nl
> *Cc:* nmusers@globomaxnm.com
> *Subject:* Re: [NMusers] Autoinduction model - An increased clearance(day
> 1- 14)
>
>
>
> Dea
ermc.nl
Cc: nmusers@globomaxnm.com
Subject: Re: [NMusers] Autoinduction model - An increased clearance(day 1-
14)
Dear Rob ter Heine,
I am working with Efavirenz, I working with 66 patients, 924 data points,
intense on day 1 and 14 and a trough con in between the two weeks.
I looke
Dear Toufigh,
Thank you very much for your email, there is wealth of information you have
provided me, I will look carefully into your suggestions and I will my model
soon.
Once again I appreciate your input.
On Mon, Mar 28, 2011 at 12:51 PM, Toufigh Gordi wrote:
> Hi Shankar,
>
> We published
Uppsala University
BMC, Box 591, 751 24 Uppsala
Sweden
From: owner-nmus...@globomaxnm.com
[mailto:owner-nmus...@globomaxnm.com]
On Behalf Of Shankar Lanke
Sent: den 28 mars 2011 15:53
To: nmusers@globomaxnm.com
Subject: [NMusers] Autoinduction model - An increased
clearance(
Hi Shankar,
We published an autoinduction model a few years back (Gordi et al., Br J Clin
Pharmacol. 2005;59(2):189-98). The original paper was based on saliva samples
but the model worked well using plasma data (Asimus and Gordi, Br J Clin
Pharmacol. 2007;63(6):758-62). We also used it to desc
> *Clinical Pharmacology, Primary Care*
>
> *(484-865-8741 / 610-265-5372)*
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> alice.nich...@pfizer.com
> --
>
> *From:* owner-nmus...@globomaxnm.com [mailto:owner-nmus...@globomaxnm.com]
> *On Behalf Of *Shankar Lanke
> *Sent:* Monday, March
Dear Philips,
Thank you very much for your input, I am re-parameterizing the model now. I
will run this model and update you soon.
Regards,
On Mon, Mar 28, 2011 at 10:48 AM, Luann Phillips <
luann.phill...@cognigencorp.com> wrote:
> Shankar,
>
> A couple of thoughts that may help.
>
> (1) If t
Dear Shankar,
I would guess that it is the term (t-tlag) which is negative in your code as
long as tmailto:owner-nmus...@globomaxnm.com] On
Behalf Of Shankar Lanke
Sent: den 28 mars 2011 15:53
To: nmusers@globomaxnm.com
Subject: [NMusers] Autoinduction model - An increased clearance(day 1- 14
2011 15:53
> *Aan:* nmusers@globomaxnm.com
> *Onderwerp:* [NMusers] Autoinduction model - An increased clearance(day 1-
> 14)
>
> Dear All,
>
> I am working on a Pop PK data where the patients are treated with HIV drug.
> An autoinduction is involved with prolonged administration of the
Shankar,
A couple of thoughts that may help.
(1) If the model is terminating with a note that states something along
the lines of 'Infinite value of objective function', this indicates that
the estimated value of TLAG for an individual is occurring at the time
of a sample.
Potential solutio
Onderwerp: [NMusers] Autoinduction model - An increased clearance(day 1-
14)
Dear All,
I am working on a Pop PK data where the patients are treated with HIV
drug. An autoinduction is involved with prolonged administration of the
drug. An increased CL is expected from day 1 to day 14.
We have
Dear All,
I am working on a Pop PK data where the patients are treated with HIV drug.
An autoinduction is involved with prolonged administration of the drug. An
increased CL is expected from day 1 to day 14.
We have intense data on day 1 and day 14 with sparse data between. Since a
lag period is i
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