RE: [NMusers] seeking help on NONMEM code for simulation of Repeated Time to Event Data

-nmus...@globomaxnm.com] On Behalf Of Leonid Gibiansky Sent: Wednesday, April 03, 2013 5:39 PM To: Yaming Hang Subject: Re: [NMusers] seeking help on NONMEM code for simulation of Repeated Time to Event Data Yaming Could you, please, add some more details about the procedure to determine the time of

[NMusers] seeking help on NONMEM code for simulation of Repeated Time to Event Data

osure, therefore I need to inverse an integral which does not have a closed form (i.e. only expressed in differential equation), how can I do that? Your help will be much appreciated! Yaming Hang

RE: [NMusers] RE: Proper way to handle the pre-first dose PK observation for non-endogenous drug

Dear Matt, Dan, Nick and Mats, Thanks for sharing your thoughts and the enlightening discussion, it is really helpful! Yaming Hang, Ph.D. Pharmacometrics Biogen Idec 14 Cambridge Center Cambridge, MA 02142 Office: 781-464-1741 Fax: 617-679-2804 Email: yaming.h...@biogenidec.com -Original

[NMusers] Proper way to handle the pre-first dose PK observation for non-endogenous drug

same as prediction, therefore the estimation of additive residual error variance has been brought down? Which way is more appropriate? I'd really appreciate it if you can share your experience/insight. Yaming Hang, Ph.D. Pharmacometrics Biogen Idec 14 Cambridge Center Cambridge, MA 02142 O

RE: [NMusers] different parameterizations of OMEGA matrix vs. chance of getting flip-flop estimates

Hi Leonid, You are right, I tried the new starting values and now the parameter estimates match each other. Thank you! Yaming Hang, Ph.D. Pharmacometrics Biogen Idec 14 Cambridge Center Cambridge, MA 02142 Office: 781-464-1741 Fax: 617-679-2804 Email: yaming.h...@biogenidec.com -Original

[NMusers] different parameterizations of OMEGA matrix vs. chance of getting flip-flop estimates

233.57 (0.06407) OMEGA(2,2) 1 () THETA3 0.09296 (0.03003) OMEGA(3,3) 1 () THETA4 0.4442 (0.03295) THETA5 0.4001(0.117) THETA6 0.6873 (0.08321) THETA7 0.3336 (0.1125) Yaming Hang, Ph.D. Pharmacometrics Biogen Idec 14 Cambridge Center Cambridge, MA 02

[NMusers] How to model delayed count data due to time needed to form an event

erval during which it first appears. What is a good approach to handle this kind of delay? Is there any published paper for similar data type? Many thanks in advance for you suggestions! Yaming Hang, Ph.D. Pharmacometrics Biogen Idec 14 Cambridge Center Cambridge, MA 02142 Office: 781-464-1741 Fax

RE: [NMusers] modeling of total concentration of two drugs with different kinetics in NONMEM

, subjects were given the second drug (IV infusion again), where the first drug is not necessarily completely cleared. Thanks, Yaming From: Retsilisitsoe Moholisa [mailto:retsilisitsoe.mohol...@uct.ac.za] Sent: Wednesday, April 25, 2012 10:23 AM To: Yaming Hang; nmusers@globomaxnm.com Subject: Re

[NMusers] modeling of total concentration of two drugs with different kinetics in NONMEM

code? Thanks, Yaming Yaming Hang, Ph.D. Pharmacometrics Biogen Idec 14 Cambridge Center Cambridge, MA 02142 Office: 781-464-1741 Fax: 617-679-3463 Email: yaming.h...@biogenidec.com<mailto:yaming.h...@biogenidec.com>