Hi Tingjie,I think this article could answer your question by indicating the
objective function used to estimate post hoc eta and how to reproduce the
estimate process in R. There were R codes example of a one-compartment PK model
with 3 etas to be estimated. Title: R-based reproduction of the e
rmula that I can use which does not have
this numerical problem?
Maybe youcan try Stu's "double exponential error model": Y = LOG(F+M)
+(F/(F+M))*ERR(1) + (M/(F+M))*ERR(2).
Best regards,
Rong Chen
School ofPharmaceutical Science
Peking University
Beijing, China
Fr
amples,
where all the off-diagonal elements are set to 0) If not, what values should I
set?
I would be very grateful for any guidances and discussion on $PRIORMany
Thanks!Rong Chen
Dear Ana,
I think the matrix presented in your email is already able to realize your idea
if you change '$OMEGA' to '$OMEGA BLOCK(6)'.A value of 0 in OMEGA matrix is
considered as it's fixed to this value.
Personall speaking, I suggest you take Elke/Rudy's advice, putting these three
in an $OMEG
