Re: [NMusers] cumulative AUC

Hi Sam, You can activate a flag from 0 to 1 from a certain timepoint (eg FLA1) and integrate the auc as follows Datdt(x)=C*FLA1 Rob Op 8 nov. 2019 om 19:16 heeft Sam Liao het volgende geschreven:  Dear nmusers, I have a question how to reset cumulative AUC in a $DES model, where DADT(4)

RE: [NMusers] Using evid 0 before dosing

Dear Carlos, You could also use an EVID=2 to do a read-out of a certain compartment. Cheers, Rob -Oorspronkelijk bericht- Van: owner-nmus...@globomaxnm.com Namens Bill Denney Verzonden: woensdag 6 november 2019 16:12 Aan: Carlos ST ; nmusers@globomaxnm.com Onderwerp: RE: [NMusers] Using

Re: [NMusers] PopPK modelling of DDIs

Hi Pieter, We did a similar analysis recently on the interaction between ritonavir/darunavir, published in JAC by Stein Schalkwijk https://academic.oup.com/jac/advance-article-abstract/doi/10.1093/jac/dky567/5304685?redirectedFrom=fulltext It is hard to separate covariance in inter-individual v

[NMusers] Radboudumc Applied Pharmacometrics Group "Hands-on pharmacometric design and power analysis for clinical trials" course

Dear all, Radboudumc Applied Pharmacometrics Group would like to invite you to the third edition of our course "Hands-on pharmacometric design and power analysis for clinical trials". The course is open for those in academia and involved in pharmacometric research. The course will be in English

[NMusers] Radboud Applied Pharmacometrics group course "Hands-on pharmacometric design and power analysis for clinical trials"

Dear all, We would like to invite you for the Radboudumc applied pharmacometrics Group course "Hands-on pharmacometric design and power analysis for clinical trials", for those in academia and involved in pharmacometric research. Date: May 4th 2018 Time: 10:00 to 17:00h Location: Radboud Univer

RE: [NMusers] Allometric scaling of renal clearance with estimated glomerular filtration rate

Dear Nick, Hans, Ruben, Max, Great to hear several approaches and opinions on the use of glomerular filtration approximations in PK modeling and scaling to body size. Thank you! I have a hard time ignoring the CKD-EPI equations (with or without cystatin C), as they are well established and prov

Re: [NMusers] Allometric scaling of renal clearance with estimated glomerular filtration rate

Hi Ruben, Interesting work, Ruben. One may indeed question the validity of glomerular filtration rate markers like cystatin C (that is only filtrated and not actively secreted) to predict PK of drugs that undergo active tubular secretion in patients with decreased renal function. When glomerula

[NMusers] Allometric scaling of renal clearance with estimated glomerular filtration rate

Dear all, I am wondering what your thoughts are on the allometric scaling of clearance of renally extreted drugs, where we have estimations renal function. Simply scaling the predicted glomerular filtration rate from, for example, the Cockroft-gault equation seems inappropriate, since weight is

[NMusers] Hands-on pharmacometric power analysis for clinical trials

Dear all, We would like to invite you for the Radboudumc applied pharmacometrics Group course "Hands-on pharmacometric power analysis for clinical trials", for those in academia involved in pharmacometric research. Date: april 14th 2017 Time: 13-17h Location: Radboud University Medical Center P

RE: [NMusers] $Error log transformed

Hi Katrin, You'll have to take the natural logarithm of your DVs I would change your error block to: $ERROR IPRED=LOG(F+1E-16) ; Protection against LOG(0) in case of dosing events etc Y=IPRED+ERR(1) ; FOR PROPORTIAL ERROR Cheers! Rob Van: owner-nmus...@globomaxnm.com [mailto:owner-nmus...@glo

RE: [NMusers] covariate on transit compartment model parameters

Hi Jing, Testing covariates on dispostition of your long acting injectable all depends on the pharmaceutics. E.g., if you have an intramuscularly injection of a nano-suspension, you might want to consider a zero order process for the release of the drug in the systemic circulation and see wheth

RE: [NMusers] Simultaneous pk model of 2 drugs

Hi all, I guess that if both drugs are given to the same person, it makes a lot of sense to perform simultaneous modeling, because of physiology, a lot of parameters will show covariance. The PK of one drug can therefore partially explain the PK of the other one (and vice versa). Cheers, Rob

RE: [NMusers] Time varying volume of distribution implementation

Dear Thorsten, As suggested by other, implementing a time dependent covariate in $DES should be the way to go. A quick workaround could also be inserting dummy observations at regular intervals in your dataset e.g. when using ADVAN5. Just out of scientific curiosity: Are you investigating total

RE: [NMusers] Some help with simulation with uncertainty using $PRIOR TNPRI

Dear Navin Goyal, Thanks for helping us out. It worked! We performed some clinical trial simulations for probability of target attainment and parameter uncertainty certainly made a difference. Sincerely, Rob Van: Heine, Rob ter Verzonden: maandag 11 april 2016 19:48 Aan: Navin Goyal Onderwerp

[NMusers] Some help with simulation with uncertainty using $PRIOR TNPRI

Dear all, I would like to perform a simulation (based on a finished model), incorporating parameter uncertainty (for all theta’s, eta’s and epsilons) with the $PRIOR TNPRI option in Nonmem V7.3, using the results of the covariance step as an input. I am still struggling how to implement this. D

[NMusers] Error in $NONPARAMETRIC

Dear all, When generating a VPC for a nonparametric ($NONPARAMETRIC subroutine on) model, I get the following error message from NONMEM 7.3.0 (installed on OSX 10.10.5, PsN 4.4.8), which doesn't occur with creating a VPC for a "normal" parametric model. > “ #TERE: > 0ERROR IN READING FILE : FI