RE: [NMusers] RE: Estimation of ke0 from raw data

2015-09-08 Thread Lommerse, JPM (Jos)
<mailto:owner-nmus...@globomaxnm.com> [mailto:owner-nmus...@globomaxnm.com] On Behalf Of Bonate, Peter Sent: Saturday, September 05, 2015 5:40 PM To: Leonid Gibiansky Cc: Lommerse, JPM (Jos); Samer Mouksassi; nmusers@globomaxnm.com<mailto:nmusers@globomaxnm.com> Subject: Re: [NMusers] RE

[NMusers] RE: Estimation of ke0 from raw data

2015-09-05 Thread Lommerse, JPM (Jos)
. Would that be feasible? Thanks, Jos From: Samer Mouksassi [mailto:samer.mouksa...@certara.com] Sent: Saturday, September 05, 2015 8:34 PM To: Lommerse, JPM (Jos); nmusers@globomaxnm.com Subject: RE: Estimation of ke0 from raw data Dear Jos, Please have a look at the algorithm detailed in the

[NMusers] Estimation of ke0 from raw data

2015-09-05 Thread Lommerse, JPM (Jos)
Hi, I have a data set containing PK concentrations and PD effect. When plotting PD as a function of PD a clear anti-clockwise hysteresis plot appears. I would like to get a (rough) estimate of the PD time delay w.r.t. the PK without using a compartmental description for the observed PK, even not

[NMusers] SE's of EBE for IPPSE method in nonmem7

2013-11-09 Thread Lommerse, JPM (Jos)
Hi I would like to obtain SE's of EBE's to be used for the IPPSE method using nonmem7. The .phi file contains the parameter estimates for the individuals as well as an "ETC" matrix. How can I convert the ETC matrix elements into individual SE's? Thanks! Jos Lommerse Notice: This e-mail messa

[NMusers] Bootstrap, re-using inital model run results

2013-02-14 Thread Lommerse, JPM (Jos)
Hi I would like to ask to NONMEM community whether it is possible to re-use the results of a nonmem model run when starting bootstrapping. As I understand, a bootstrap run using PsN starts with a single calculation of the model of interest and data set as is. Once this initial model run has comp