Dear Joe,
Thank you for your reply. You are right that one can model renal clearance
using SeCr as you described. In fact, your approach is number three, after
Nick's and mine (the order is purely arbitrary).
It would be interesting to see real life examples and Monte Carlo
simulations to see
Dear Matt,
I'm not quite sure that I fully understand your question. I would say that a
changing renal function and a changing weight over time can be handled as
described earlier by Nick Holford, or by the modified approach I suggested. An
important point is how to express renal function.
Ni
Dear Nick,
In your reply to Siwei, you proposed the following code:
$PK
; CL=(CLnon-renal*f(age) + CLrenal*f(renal_function)) * allometric WT
CL=(THETA(1)*EXP(THETA(2)*(AGE-40)) + THETA(3)*CLCR/100)*(WT/70)**0.75
I would like to make a comment on the coding of the renal function. If CLCR
is
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