RE: [NMusers] single-patient AUC

Dear Simon, Thanks for the information. I will check it. Best! Shirley From: Simon Davis [mailto:simon.da...@certara.com] Sent: Monday, September 03, 2012 5:36 AM To: Hou, Xiaoli Shirley; NONMEM Subject: RE: [NMusers] single-patient AUC Dear Shirley, If you

RE: [NMusers] single-patient AUC

Dear NM-Users, I am doing a simulation using R, in which the within and between subject variations, "EPSILON" and "OMEGA", are needed. They are automatically listed in the ***.lst file of the NONMEM outputs. Is there a way I can read them from my NONMEM output into R? Thanks, Shirley Dr. Xiao

[NMusers] medians of the simulation in VPC are systematically below the medians of the observations when the model fit looks fine.

Dear All, I have built a non-compartment model, in which the medians of IPREDs and Observations are very close. But in VPC plot, the medians of simulations are systematically below the medians of observations Any idea why it happens? Thanks. Shirley Notice: This e-mail message, together wit

[NMusers] Modeling a concentration curve with secondary peaks?

I need help for modeling a concentration curve with secondary peaks. What models could I use? I tried two compartment models, but it couldn't capture the secondary peaks. Suggestions or recommendations are highly appreciated. Thanks. Dr. Xiaoli Shirley Hou Senior Biometrician, Biometrics Re