Dear all,
PAGE is getting closer and the available seats in the Simulo (Exprimo's unique
clinical trail simulator) workshop getting fewer. Please save you seat now!
Check out the details here:
https://exprimo.com/article/two-day-clinical-trial-simulation-course-page-2018
SGS Exprimo is running a
yway. Good luck with your
project!
Please excuse my brevity, this was sent from a mobile device
From: Tingjie Guo
Sent: Friday, April 13, 2018 5:20:40 PM
To: Jakob Ribbing
Cc: Faelens, Ruben (Belgium); nmusers@globomaxnm.com
Subject: Re: [NMusers] ETAs & SIGM
Hi Tingjie,
A lot of great tips and explanations already. Just wanted to add my two cents.
POSTHOC will estimate the most likely ETA for each individual, taking into
account the known population parameters THETA and OMEGA. “Most likely” means:
1. An individual parameter as close as possible
Dear Christina,
I would love to learn a bit more about this, and an open discussion on this
list is probably the best way.
Could you elaborate how specifically the open source nature of R causes concern?
See the nice documentation from the R project core team at
https://www.r-project.org/doc/R-
Dear colleagues,
In the context of the next PAGE meeting, SGS Exprimo is running a two-day
Clinical Trial Simulation course on Monday and Tuesday 28-29 May.
* The course on Monday will introduce attendees to Simulo, a PK-PD-Disease
model simulator developed for 6 years and now available
Hi Penny,
Nonmem indeed calculates each subject one after the other. The random values
will therefore change. Maybe you can set the random seed every time you
simulate t=0, based on the subject ID?
This may also depend on your data file; have you tried ordering on time (so the
first 50 rows are
Hi Paul,
How are you launching jobs?
Are you launching nmfe using qsub -pe myqueue 4 ./nmfe-launch.sh ?
I may be mistaken, but I assume that SGE should automatically handle this sort
of thing, no?
If you specified the correct number of slots in the cluster queue, only that
amount of cores shoul
Dear group,
The MPI library of choice for Nonmem has been MPICH2 for quite some time now.
Since the last release of MPICH2 on April 2013, the package has been
unsupported on Windows. The developers of MPICH2 actually recommend migrating
to MS-MPI.
By adding the required libraries to the compile
Dear Adedeji,
This is probably the cause of the problem:
Fatal Error: Cannot read module file 'fsizes.mod' opened at (1), because it was
created by a different version of GNU Fortran
Every time you install NONMEM, it will recompile the standard functions modules
using your current compiler. The
Hi Pavel,
In general, parallelization discussions always revolve around the following
question: “Can you create independent blocks of work?”
You should make a clear distinction here between parallelizing nonmem, and
running several nonmem runs in parallel. Let’s talk about estimating of a
singl
Dear NONMEM users,
We all know how difficult it is to simulate full drug trials using NONMEM. It
is often necessary to generate the full dosing scheme(s) beforehand, and
response-based dose adaptation requires iteratively rerunning your model until
you have the results you are happy with.
At S
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