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Hi Anna,
That you want to explore covariate relationships on a parameter suggests that
you believe your data contain plenty of information about the parameter.
Therefore do you really need to use a prior on the parameter(s) in question? A
little more info around what your “base” model is and wh
Dear NMusers community,
I'd like to alert you to another position that has opened at Lilly:
Position: Research Scientist PK/PD
Responsibilities
At Lilly, we unite caring with discovery to make life better for people around
the world. The Biotechnology Research/ADME group is responsible for eva
Dear Anna,
The times I have used SCM in combination with a frequentist prior, it has been
only to test if a new population is different (i.e. the data used to generate
the prior were all of a different population, e.g. healthy volunteers and other
indications than the currently-investigated pop
Dear NMusers
I am wondering about the inclusion of covariates with the $PRIOR subroutine.
The article "Use of Prior Information to Stabilize a Population Data
Analysis" (Gisleskog, Karlsson, Beal 2002) states that Stepwise Covariate
Modelling (SCM) is possible on a parameter estimated with prio