Registration for a course on Covariate model building and evaluation in
Glasgow June 10-11 has just opened at www.uppsala-pharmacometrics.com
Best regards,
Mats
Mats Karlsson, PhD
Professor of Pharmacometrics
Dept of Pharmaceutical Biosciences
Faculty of Pharmacy
Uppsala University
My thanks to Leonid and Mats. Leonid points out that the equations
for CL were not equivalent in the simulation and estimate runs
SIM
CL=(Z*(CL1 + CLr) + (1.0-Z)*(CL2 + CLr))* EXP(ETA(i))
; correct
EST
CL=((Z*CL1 + CLr) + ((1.0-Z)*CL2 + CLr))*EXP(ETA(i))
; w
Dear Paul,
All OMEGAs are zero during simulation? So I'm thinking about what that would
mean for ETA_CL if is not fixed to zero when fitting; what would happen to
ETA_CL if not all estimated subgroups are equal to the simulated ones, or the
effect of a less than perfect fit on ETA_CL might be d
Dear Paul,
I don't think you should expect the same ETA for CL under the two mixtures,
but estimate two separate ones as shown below.. Note also that the estimate
of ETA you get in the table file is the one from the most probable mixture
component (whereas the contribution from both mixture compon
Well, it was the wrong guess, MIXNUM should work
--
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web:www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel:(301) 767 5566
should it be IF(MIXEST.EQ.2) Z=0 for the fitting run?
On 5/7/2013 1
should it be IF(MIXEST.EQ.2) Z=0 for the fitting run?
--
Leonid Gibiansky, Ph.D.
President, QuantPharm LLC
web:www.quantpharm.com
e-mail: LGibiansky at quantpharm.com
tel:(301) 767 5566
On 5/7/2013 11:31 AM, Paul Hutson wrote:
Dear Users:
I note t
Dear Users:
I note the Jan 26, 2013 response to Nick Holford's query about results
from the use of the $MIX mixture model for simulation. I have created a
data set of N=100 subjects using R to randomly distribute their
covariates, both continuous and categorical. I then ran the following
sim
