Re: [Freesurfer] lme model for within-subjects repeated measures design

2016-04-21 Thread Martin Reuter
Thanks, what I mean is in order to quantify a treatment effect for the subjects that received treatment at T0, you would need another scan before that (Tminus1). You would need three time points: group1: baseline, placebo, treatment group2: baseline, treatment, placebo you could then test if

Re: [Freesurfer] lme model for within-subjects repeated measures design

2016-04-21 Thread Martina Papmeyer
Hi Martin Thank you very much for your response! To clarify the design: There are 44 subjects, all have been scanned twice and thus have repeated measures of cortical thickness. 22 subjects were first (T0) scanned 2 hours after a placebo treatment. Some days later, the identical subjects were

Re: [Freesurfer] lme model for within-subjects repeated measures design

2016-04-21 Thread Martin Reuter
Hi Martina, so you don't have a baseline (no treatment) measurement? If you have a treatment at T0, you mean during an interval before T0, right? But since you did not scan before that treatment, you cannot quantify that change? The design is not clear to me. About the random effect (with on