Re: [Freesurfer] comparison of mean thickness of gyri in two groups

2009-11-02 Thread Michael Harms
Well, if doing a thickness analysis, then mean cortical thickness seems the "natural" covariate to use, if you want to answer the question whether the thickness difference in a region is "beyond" any difference that would be predicted based on mean cortical thickness. This is especially relevant

Re: [Freesurfer] comparison of mean thickness of gyri in two groups

2009-11-01 Thread Mehul Sampat
Thank you for your suggestions Bruce and Mike. Mike, could you please provide the motivation behind your suggestion of using mean cortical thickness as a covariate ? Let's consider this is the context of a simple example. Let's say we compare the mean thickness of the pre-central gyrus in patien

Re: [Freesurfer] comparison of mean thickness of gyri in two groups

2009-11-01 Thread Michael Harms
To me, it makes much more sense to use mean cortical thickness as a covariate for thickness-based analyses. cheers, Mike H. > Hi Mehul, > > the MNI group had an abstract showing that thickness didn't need eTIV > correction at HBM a number of years ago, and it has been our experience > as well. >

Re: [Freesurfer] comparison of mean thickness of gyri in two groups

2009-10-31 Thread Bruce Fischl
Hi Mehul, the MNI group had an abstract showing that thickness didn't need eTIV correction at HBM a number of years ago, and it has been our experience as well. cheers, Bruce On Sat, 31 Oct 2009, Mehul Sampat wrote: > Hi Folks, > > If am comparing the mean thickness for certain gyri (pre-cent

[Freesurfer] comparison of mean thickness of gyri in two groups

2009-10-31 Thread Mehul Sampat
Hi Folks, If am comparing the mean thickness for certain gyri (pre-central, post-central) in a controls versus patients. I obtain the thickness measurements from lh.aparc.a2009s.stats and rh.aparc.a2009s.stats I was wondering if I need to normalize these thickness measurement with the estimated to