Re: [Freesurfer] 20% changes

2011-07-29 Thread Bruce Fischl
Ji Jessica, that's pretty low contrast. I would also bet that it's low bandwidth and hence you have big temporal lobe B0 distortions that will change with subject positioning. Are you stuck with this data going forward, or can you change the acquisition parameters? If not, I think you will hav

Re: [Freesurfer] 20% changes

2011-07-28 Thread Bruce Fischl
Hi Jessica the problem may be data quality! At 1.5T with a volume coil we would typically get 2 scans to average. A TR of 14 is pretty short and will reduce the SNR, and a TE of 6 is quite long and will reduce contrast. Can you send us a tif of one slice to look at? Bruce On Thu, 28 Jul 201

Re: [Freesurfer] 20% changes

2011-07-28 Thread Jessica Liu
Hi Martin, When I did longitudinal analyses in the past, the output was very strange even though I think I did everything correctly. If it's not too much trouble for you, could you please take a look at my data and tell me what I've done wrong? Since the files are so large, how would I send over

Re: [Freesurfer] 20% changes

2011-07-28 Thread Martin Reuter
Hi Jessica, I'd recommend to run the -base and the -long on these and see what happens. If you then still see these differences, maybe we can take a look at your data to figure out what causes this. It could be that the WM segmentation fails somewhere. Anyway, the longitudinal stream should help f

Re: [Freesurfer] 20% changes

2011-07-27 Thread Jessica Liu
Hi Bruce, Well for one of the subjects, the total temporal lobe volume from the first scan was 149937 mm3, and the second scan's total temporal lobe volume was 183121 mm3. These numbers were found by summing the volumes from the entorhinal, fusiform, parahippocampal, temporal pole, transverse tem

Re: [Freesurfer] 20% changes

2011-07-27 Thread Bruce Fischl
how are you computing the 20% difference? We definitely don't see this, and Martin has done extensive testing of repeatability. Bruce On Wed, 27 Jul 2011, Jessica Liu wrote: Hi Martin, Thanks for getting back to me.  Actually I have two young controls who have 20% differences between two s

Re: [Freesurfer] 20% changes

2011-07-27 Thread Jessica Liu
Hi Martin, Thanks for getting back to me. Actually I have two young controls who have 20% differences between two scans a day apart. Visually, there are not abnormalities for the surfaces and hippocampus in both subjects i.e. on tkmedit, the color of the hippocampus area (yellow) looks alright t

Re: [Freesurfer] 20% changes

2011-07-27 Thread Martin Reuter
Hi Jessica, I don't think this is normal. Is this a single subject? Of course in a single subject lots of stuff can go wrong. Are the surfaces correct? And the hippo label? Are there motion artifacts in the image etc. Anyway, you should process this with the longitudinal stream: http://freesurfer

[Freesurfer] 20% changes

2011-07-27 Thread Jessica Liu
Hi, We found 20% differences in temporal lobe brain volume and ca. 5% difference in the hippocampus volume between two data sets of a young normal volunteer scanned 2 days apart. We use the one-step 19 hours recon-all -all procedure and directly sum select values taken from the lh.aparc.stats, rh