We are currently seeking a Protein Crystallographer to join the
crystallography team. You will be responsible for the structure
determination of membrane proteins to support Sosei Heptares’ drug
discovery efforts. This is an exceptional opportunity to participate in
pioneering science with an Indus
I am refining a structure at 2.2A resolution. I find that all my arginines show
distortion after refinement with refmac5 even though they fit into the density
really well.
This is latest version of ccp4 8.00 running on windows 10. Is my library
messed up in refmac5? Any other ideas?
#
Dear James,
This is coming closer to your concept:-
https://www.cos.io/initiatives/registered-reports?_ga=2.256611083.1499354793.1646731928-1289064925.1646731928
which I learned about in the current issue of Research Professional:-
https://research.jiscinvolve.org/wp/2022/03/08/octopus-jisc-and-ukr
>So, 2nd question is: would you do it? Would you upload your application
>into the public domain for all to see? What about the reviewer comments?
>If not, why not? Afraid people will steal your ideas? Well, once
>something is public, its pretty clear who got the idea first.
I do not think this (
Dear Debanu,
There is indeed much at stake here.
Would I do it now, share my proposals, No.
Would I do it if funders’ rules required it. Yes.
When might funders’ rules require it eg when Tax payers insist that the
priority is achieving societal goals asap. Might that happen in the foreseeable
f
Dear John,
For sure it is an aspiration as a society and as a civilization: to think
beyond individual nations. And for that we have some examples as you
mentioned at the scientific (IUCr, PDB) and political level (UN). We also
have the EU, ASEAN, NATO, etc.
However, despite having these organiza
Good evening
We are seeking to appoint a Postdoctoral fellow for the Protein
Crystallography Small Research Facility (PX-SRF), under the supervision of
Professor Frank von Delft. The successful candidate will support all
PX-SRF related activities, with the predominant focus on the projects in
t
Thinking about it some more, I think all the materials (patentable IP or
trade secrets, which in the US are IP and under Defense of Trade Secrets
Act) of a researcher are owned by the university. So just getting across
tech transfer/IP of individual univs would be a massive hurdle before
thinking o
Dear Debanu
The UNESCO initiative as I mentioned is very interesting. I will offer alerts
at key moments.
At International Data Week in S Korea just concluded the Plenary session was on
Open Science around the World. Africa, Latin America, S Korea and Malaysia
talks all were defining open scien
It's the library:
https://doi.org/10.1107/S2059798320013534
And it is not something that is terribly easy to fix. Arginine just has
internal clashes so that plane is only flat sometimes. This is a lot of
what led to the "Conformation Dependent Library", which I don't think is
set up under CCP4
Hey Debanu,
Hmm. Last time I did it I didn't have to go through any IP lawyers to
upload a pre-print to biorxiv. What I was thinking of is something
similar to that. Researchers, on their own, deciding to upload their
applications and reviews. What would be the motivation? Well, I imagine
Hi James,
I think it is quite different for publications/open publications
(investigator initiated submissions on outcomes of grant-funded research,
which are meant for public dissemination, even though all patentable IP is
still employed-owned, whether a university, a national lab or a company) v
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