Re: [ccp4bb] advice for crystallizing hydrophobic small molecules

2007-07-19 Thread Jose Antonio Cuesta-Seijo
And here some more small molecule crystallization links. http://xray.chem.ufl.edu/growing%20tips.htm http://mic.ucla.edu/x-ray%20diffraction/tutorials_crystalgrowing.htm http://www.nottingham.ac.uk/~pczajb2/growcrys.htm Jose Antonio Cuesta-Seijo On Jul 18, 2007, at 5:56 PM, Green, Todd wrote:

Re: [ccp4bb] advice for crystallizing hydrophobic small molecules

2007-07-19 Thread Jose Antonio Cuesta-Seijo
Hello Todd. An experienced synthetic chemist is your best source of help here, but otherwise have a look at these links. And greasy molecules are no problem. Organic chemists crystalize them like candy! http://www.xray.ncsu.edu/GrowXtal.html http://web.mit.edu/x-ray/cystallize.html http://64

Re: [ccp4bb] advice for crystallizing hydrophobic small molecules

2007-07-18 Thread Li Sheng
Anthony had given some good advice. In addition, Any organic solvent may be helpful. We often use methanol and chloroform. = 2007-7-19 6:12, your message: Re: [ccp4bb] advice for crystallizing hydrophobic small molecules= Hi Todd I have worked in the past

Re: [ccp4bb] advice for crystallizing hydrophobic small molecules

2007-07-18 Thread Anthony Addlagatta
Hi Todd I have worked in the past with crystallization of dozens of small molecules, several of them steroids which are hydrophobic. What I did was, first get the small molecule into the solution. The solvent can be dimethyl formamide, dimethyl sulfoxide, chloroform or anything that I ca