Re: [ccp4bb] disordered cysteine

2024-04-22 Thread MARCHOT Pascale
C.UK Objet : Re: [ccp4bb] disordered cysteine Ce mail provient de l'extérieur, restons vigilants Dear Oliviero, For sure cysteines can be disordered. Sometimes you can find one conformation reduced and another conformation oxidised if the cysteine is solvent exposed. Also in well-resolved

Re: [ccp4bb] disordered cysteine

2024-04-22 Thread Maria Håkansson
Dear Oliviero, Resending the message since I am not sure you got it. For sure cysteines can be disordered. Sometimes you can find one conformation reduced and another conformation oxidised if the cysteine is solvent exposed. Also in well-resolved structures you can see a cysteine taking part in

Re: [ccp4bb] disordered cysteine

2024-04-22 Thread Maria Håkansson
Dear Oliviero, For sure cysteines can be disordered. Sometimes you can find one conformation reduced and another conformation oxidised if the cysteine is solvent exposed. Also in well-resolved structures you can see a cysteine taking part in a disulphide bond, but only partially, one conformatio

[ccp4bb] disordered cysteine

2024-04-22 Thread Italo Carugo Oliviero
Dears, is it possible for a cysteine to be conformationally disordered? It seems strange to me. If it were, it would almost certainly be exposed to the solvent and thus easily oxidized irreversibly. Do you perhaps have any information on conformationally disordered cysteines? I thank you, Oliviero